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Chinese medicine composition for treating apoplexy and its prepn process and use

A technology of composition and traditional Chinese medicine, which is applied in the field of Chinese medicine composition for the treatment of stroke, to achieve the effect of increasing extraction rate, improving curative effect and overcoming damage

Active Publication Date: 2007-09-26
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current clinical stroke is mainly manifested by blood stasis, and Buyang Huanwu Decoction has certain limitations in the current clinical stroke treatment.

Method used

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  • Chinese medicine composition for treating apoplexy and its prepn process and use
  • Chinese medicine composition for treating apoplexy and its prepn process and use
  • Chinese medicine composition for treating apoplexy and its prepn process and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The proportioning composition of composition consists of:

[0033] Leech 600g

[0034] Chuanxiong 600g

[0035] Danshen 400g

[0036] Astragalus 400g

[0037] Appropriate amount of starch

[0038] Micropowder silica gel amount

[0039] A total of 1000 capsules were made (0.25g / capsule)

[0040] Preparation method: 1) Take the coarse powder of the leech medicinal material in proportion, add 6 times the amount of 0.1% sodium benzoate aqueous solution, stir at 37°C for 20 hours (100 rpm), centrifuge for 30min (6000 rpm), discard Remove the precipitate, pre-filter the supernatant through a 1um pore size membrane, filter the filtrate through a 0.2μm pore size membrane to sterilize, and then pass through an ultrafilter (cut-off specification: 6000-10000) to concentrate about 600ml (relative density 1.15, room temperature), The concentrated solution is freeze-dried into powder to obtain leech freeze-dried powder;

[0041] 2) Take the coarse powder of Rhizoma Chuanxiong,...

Embodiment 2

[0044] The proportioning composition of composition consists of:

[0045] Leech 600g

[0046] Chuanxiong 600g

[0047] Danshen 400g

[0048] Astragalus 400g

[0049] Micropowder silica gel amount

[0050] Appropriate amount of starch

[0051] A total of 1000 capsules were made (0.25g / capsule)

[0052] Preparation method: 1) Take the coarse powder of leech medicine in proportion, add 6 times the amount of normal saline, stir at 37°C for 20 hours (100 rpm), centrifuge for 30 minutes (6000 rpm), discard the precipitate, and put The supernatant is pre-filtered through a 1um pore size membrane, the filtrate is sterilized by filtration through a 0.2μm pore size membrane, and then concentrated by an ultrafilter (cut-off specification: 6000-10000) to about 600ml (relative density 1.15, room temperature), and the concentrate is freeze-dried into powder to obtain leech freeze-dried powder;

[0053] 2) Take the coarse powder of Rhizoma Chuanxiong, Salvia miltiorrhiza and Radix Ast...

Embodiment 3

[0056] The proportioning composition of composition consists of:

[0057] Fresh leech 6000g

[0058] Chuanxiong 600g

[0059] Danshen 400g

[0060] Astragalus 400g

[0061] Micropowder silica gel amount

[0062] Appropriate amount of starch

[0063] A total of 1000 tablets (0.30g tablets) were made

[0064] The extraction method of the active ingredient is the same as in Example 1; the leech freeze-dried powder obtained in step 1) is uniformly mixed with the Rhizoma Chuanxiong mixed powder obtained in step 2, and then the starch and 10w / w% micropowder accounting for 20w / w% of the total weight are added Silica gel, mixed evenly, passed through an 80-mesh sieve, compressed into tablets, and coated with enteric coating.

[0065] The therapeutic effect of the pharmaceutical composition of the present invention on apoplexy will be verified through the following drug efficacy test examples or toxicity test examples. The drug used in the test example is the dry powder of the c...

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Abstract

The Chinese medicine composition for treating apoplexy has leech as main medicine component and excellent preventing and treating effect on apoplexy, especially ischemic apoplexy caused by blood stasis and Qi deficiency. Research, including toxicological research, shows that the composition has determined curative effect, high safety without toxicity and excellent preventing and treating effect especially on ischemic apoplexy caused by blood stasis and Qi deficiency.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating stroke. More specifically, the present invention relates to a traditional Chinese medicine composition using leech as the main medicine, its preparation method and its use. Background technique [0002] Cerebrovascular disease is one of the important chronic diseases that endanger human health in the world today, and it is also one of the three major causes of global population death. According to the data released by the World Health Organization in 1979, among the 57 countries in the world, 40 countries rank among the top three in terms of death from stroke. In 1995, my country's statistical data showed that: stroke ranks first in urban areas and second in rural areas. It is estimated that there are currently 5 to 6 million stroke patients, and 3 / 4 of the survivors have varying degrees of disability [4] . Due to the acute onset, high mortality rate and high disabilit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/481A61K36/236A61K35/62A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 朱学东顾伟伟夏培源刁勇
Owner LUNAN HOPE PHARM CO LTD