Calcium alginate/poly arginine-chitin glycan composite medicine release -controlled microcap sule and preparing method thereof

A technology of calcium alginate and polyarginine, which is applied in the directions of drug delivery, pharmaceutical formulations, and medical preparations with non-active ingredients to achieve a smooth surface

Inactive Publication Date: 2007-12-19
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a calcium alginate/polyarginine-chitosan compound drug controlled release microcapsule and its preparation method,

Method used

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Examples

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Embodiment Construction

[0019] The following is the specific implementation steps of the present invention taking the two-component single-layer membrane composite microcapsule as an example (taking bovine hemoglobin as the representative of protein and polypeptide drugs as an example):

[0020] First, filter the 1.8% sodium alginate solution through 0.8 μm, 0.45 μm, and 0.22 μm, add bovine hemoglobin to make the content 1 mg / mL, mix well, remove bubbles by ultrasonic waves, transfer 4 mL into a syringe, The drop generator is dropped into 200mL of 1.5% (w / v) calcium chloride solution containing 0.2% Tween80 dispersant, and a gelation reaction occurs to form calcium alginate gel beads with a certain particle size.

[0021] Second, soak the prepared calcium alginate beads in 20 mL of 5 mg / mL bovine hemoglobin solution and let stand for adsorption for more than 12 hours.

[0022] Third, after the adsorbed beads were quickly washed twice with normal saline, 20 mL of a mixture containing 0.6% chitosan and...

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PUM

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Abstract

The invention refers to calcium alginate/PAA-chitosan compound drug controlled-release microcapsule and making method. The microcapsule is double-component single-layer film compound one or double-component double-layer film compound one. It uses static combination, uses PAA-chitosan as film material, and uses high-pressure static liquid drop generator to make the microcapsule, using sodium alginate to decorate surface, the particle size even and controllable, within 200-1000 mum, and the particle surface glabrous.

Description

technical field [0001] The invention relates to microcapsules with calcium alginate as gel beads and polyarginine-chitosan as capsule walls and a preparation method thereof, in particular to microcapsules and preparation methods for drug controlled release. Background technique [0002] Microencapsulation technology is a technology that completely encapsulates dispersed solid material particles, liquid droplets or gases in a film to form spherical microcapsules. Utilizing the functions of protecting and controlling substance diffusion of the microcapsule membrane, microcapsules have been widely used in the pharmaceutical industry, industry, agriculture and daily necessities, especially in drug controlled release systems. [0003] Chitosan has good biocompatibility and can be biodegraded, and the degradation products are non-toxic. Polyarginine and its degradation products not only have good biocompatibility and non-toxicity, but also can improve the immune function of wound...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/12A61K9/52
Inventor 王士斌翁连进陈爱政陈梅英
Owner HUAQIAO UNIVERSITY
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