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Quality control method of eucommia bark blood pressure lowering preparation for treating high blood pressure

A quality control method and technology for hypertension, applied in the direction of testing pharmaceutical preparations, medical preparations containing active ingredients, measuring devices, etc., can solve problems such as poor reproducibility, low specificity of quality standards, poor stability, etc.

Active Publication Date: 2008-02-13
贵州汉方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original standard is included in the sixth volume of drug standards of the Ministry of Health. The quality standard has shortcomings such as low specificity, poor reproducibility, and poor stability.

Method used

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  • Quality control method of eucommia bark blood pressure lowering preparation for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Example 1 of the present invention: detection of Eucommia antihypertensive capsules, Eucommia antihypertensive capsules were prepared according to the applicant's production process and provided directly by the applicant.

[0108] Identification: (1) Take 3g of the content of this product, grind it finely, add 30ml of ether, heat and reflux for 30 minutes, filter, discard the ether solution, add 30ml of methanol to the medicinal residue, heat and reflux for 40 minutes, filter, and evaporate the filtrate to dryness. Add 30ml of water to the residue to dissolve, filter, adjust the pH value of the filtrate to 2 with dilute hydrochloric acid, extract 3 times with ethyl acetate, 25ml each time, combine the ethyl acetate solution, evaporate to dryness, add 1ml of methanol to the residue to dissolve, as the test product solution. Take another 1 g of Scutellaria baicalensis reference medicinal material, and make a reference medicinal material solution in the same way. Then tak...

Embodiment 2

[0118] Example 2 of the present invention: Detection of Compound Eucommia Tablets (Eucommia Jiangya Tablets); Compound Eucommia Tablets (Eucommia Jiangya Tablets) are produced and prepared by our company according to the standards of the National Pharmacopoeia.

[0119] Identification: (1) Take 20 tablets of this product, remove the sugar coating from the sugar-coated tablets, grind finely, weigh 0.1g, add 5ml of ether, heat and reflux for 10 minutes, filter, discard the ether solution, add 5ml of methanol to the dregs, and heat and reflux for 10 minutes Minutes, filter, evaporate the filtrate to dryness, add 1ml of water to the residue to dissolve, filter, adjust the pH value of the filtrate to 1 with dilute hydrochloric acid, extract once with ethyl acetate, 25ml each time, combine the ethyl acetate liquid, evaporate to dryness, the residue Add methanol 0.5ml to dissolve, as the test solution. Take another 0.1 g of Scutellaria baicalensis reference medicinal material, and ma...

Embodiment 3

[0129] Example 3 of the present invention: detection of Eucommia antihypertensive granules. Eucommia antihypertensive granules are prepared according to our company's production process and provided directly by our company.

[0130] Identification: (1) Take 20g of this product, grind it finely, add 50ml of ether, heat and reflux for 60 minutes, filter, discard the ether solution, add 50ml of methanol to the drug residue, heat and reflux for 90 minutes, filter, evaporate the filtrate to dryness, add water to the residue 60ml to dissolve, filter, adjust the pH value of the filtrate to 6 with dilute hydrochloric acid, extract 3 times with ethyl acetate, 40ml each time, combine the ethyl acetate solution, evaporate to dryness, add 5ml of methanol to the residue to dissolve, as the test solution ; Take another 3 g of Scutellaria baicalensis reference medicinal material, and make a reference medicinal material solution in the same way; then take an appropriate amount of baicalin refe...

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Abstract

A quality control method for the Chinese medicine 'Antihypertenssive Duzhong medicine' to treat hypertension includes such steps as examining its characteristics, identifying scutellaria root, uncaria stem with hooks and motherwort, and measuring the content of scutelloside.

Description

Technical field: [0001] The invention relates to a quality control method of an Eucommia antihypertensive preparation for treating hypertension, in particular to the quality control of a pharmaceutical composition for treating hypertension, and belongs to the field of drug quality standards. Background technique: [0002] The Eucommia antihypertensive preparation is a modified product of "Compound Eucommia Tablets (Eucommia Antihypertensive Tablets)", which is modified by the applicant's unit. The original standard is included in the sixth volume of drug standards of the Ministry of Health. The quality standard has shortcomings such as low specificity, poor reproducibility, and poor stability. We have improved the quality standards of the original tablet and modified preparations, added TLC identification and content determination, and overcome the shortcomings of the original quality standards. The improved standard has strong operability, good reproducibility, small measu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K36/46A61P9/12G01N30/90G01N33/15
Inventor 张劲翼
Owner 贵州汉方药业有限公司
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