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Magnesium iso-glycyrrhetate gel and its preparing method and use

A magnesium glycyrrhizinate gel, the technology of magnesium glycyrrhizinate gel, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., to achieve the effects of strong adhesion, good effect, and rapid action

Active Publication Date: 2008-04-16
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, magnesium isoglycyrrhizinate only has its injection in development for the treatment of hepatitis, and there is no report on the development of its external preparation

Method used

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  • Magnesium iso-glycyrrhetate gel and its preparing method and use
  • Magnesium iso-glycyrrhetate gel and its preparing method and use
  • Magnesium iso-glycyrrhetate gel and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation method is as follows:

[0033] 1. Dissolve the formula amount of propylparaben in the formula amount of propylene glycol, and dissolve the formula amount of EDTA disodium salt in an appropriate amount of distilled water, and mix the two. Add the formula amount of glycerin and mix well.

[0034] 2. Slowly put the formula amount of Carbomer 940 into the upper solution, stir continuously, and let it stand for more than 24 hours to obtain a blank glue for use.

[0035] 3. Slowly add 10% sodium hydroxide solution to the blank gel under stirring, and adjust the pH to 6.1.

[0036] 4. Dissolve the prescribed amount of magnesium isoglycyrrhizinate in an appropriate amount of distilled water, and slowly add it to the blank gel with adjusted pH under constant stirring.

[0037] 5. Under constant stirring, slowly add the formula amount of oleic acid.

[0038] 6. Weigh and add distilled water to the total weight.

Embodiment 2

[0041] Preparation:

[0042] 1. Put the formula amount of EDTA disodium salt into an appropriate amount of distilled water, stir to dissolve; then put the formula amount of chlorocresol into the formula amount of glycerin, heat and stir until completely dissolved. Mix the two.

[0043] 2. Put the formula amount of sodium carboxymethyl cellulose into the upper solution, and keep stirring until it is completely dissolved to obtain a blank glue for use.

[0044] 3. Dissolve the prescribed amount of magnesium isoglycyrrhizinate in an appropriate amount of distilled water, and slowly add it to the blank glue under constant stirring.

[0045] 4. Under constant stirring, slowly add the formula amount of lauroketone.

[0046] 5. Weigh and add distilled water to the total weight.

Embodiment 3

[0049] Preparation:

[0050] 1. Put the formula amount of calcium sodium salt of EDTA into an appropriate amount of distilled water and stir to dissolve. Then add the formula amount of propylene glycol and mix well.

[0051] 2. Put the formula amount of hypromellose into the upper solution, stir continuously, and wait until it is completely dissolved to obtain a blank glue for use.

[0052] 3. Dissolve the magnesium isoglycyrrhizinate in the formula amount and the remaining amount of distilled water in the formula amount, and slowly add it to the blank glue under constant stirring.

[0053] 4. Dissolve the formula amount of lauroketone in the formula amount of anhydrous ethanol. It was slowly added to the above gel with constant stirring.

[0054]5. Weigh and add absolute ethanol to the total weight.

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Abstract

The present invention relates to the field of medicine preparation, and discloses a kind gel containing magnesium isoglycyrrhetate and its preparation process and application. The prepared gel has stable characteristic and convenient use. Animal experiment shows that the gel of the present invention can treat psoriasis, chronic eczema and dermatitis, contact dermatitis and other allergic dermatosis.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a magnesium isoglycyrrhizinate gel and a preparation method and application thereof. technical background [0002] Glycyrrhizic acid has pharmacological effects such as anti-inflammatory, anti-allergic, immune regulation, anti-oxidation and inhibition of mutation. Intravenous administration of diammonium glycyrrhizinate has been clinically used to treat psoriasis and dermatitis, such as eczema, with good curative effect. Oral preparations of glycyrrhizic acid, such as compound glycyrrhizin tablets (trade name Meineng), are also used clinically to treat skin diseases such as psoriasis and eczema, but these glycyrrhizic acid preparations have certain side effects, such as water and sodium retention, etc. patient compliance with medication. At present, there is no glycyrrhizic acid topical preparation product on the market. [0003] Magnesium isoglycyrrhizinate is a new...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/566A61K9/00A61P17/10A61P17/00A61P37/08
Inventor 程艳菊张来芳吴锡铭王佩
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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