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Porous antisticking agar-collagen film and its prepn process

An anti-adhesion film and agar technology, which is applied in the field of biomedical materials, can solve the problems of affecting the normal healing of tissues and hindering the normal healing process of tissues, and achieve the effect of low cost, convenient operation and good flexibility

Inactive Publication Date: 2008-11-19
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, the existing technologies either use physical barriers to prevent the infiltration of cells into the healing tissue, but also hinder the normal healing process of the tissue; or prevent the proliferation of cells by inhibiting angiogenesis with chemical drugs, which also affects the normal healing of the tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of agar and collagen porous anti-adhesion membranes

[0027] Agar gum was dissolved in hot water at 85°C with a concentration of 1.5% by weight, and type II collagen was swelled in 0.04M acetic acid solution with a concentration of 0.5% by weight;

[0028] Mixing the agar gel and type II collagen processed in step (1) in a mass ratio of 1:5 and pouring them into a mold for molding;

[0029] Put it into a freeze dryer, freeze at -35°C for 3 hours, pump air at 0°C for 18 hours, and freeze-dry to form a porous anti-adhesion film.

[0030] The porous anti-adhesion film has an area of ​​20cmX10cm and a thickness of 0.2-0.4mm.

[0031] tendon surgery anti-adhesion

[0032] The cut size is length=operated tendon length, width=2 times the circumference of the tendon, and ethylene oxide is sterilized for later use. After removing blood, fluid, etc. after the operation, the membrane is wrapped in the sick area, and the membrane is automatically attached to the tend...

Embodiment 2

[0034] Preparation of agar and collagen porous anti-adhesion membranes

[0035] Agar or its purified product is dissolved in hot water at 95°C with a concentration of 0.8% by weight, and soluble gelatin is dissolved in water with a concentration of 0.6% by weight;

[0036] Mix the processed agar or its purified product with soluble gelatin in the step (1) according to a mass ratio of 2:1 and pour it into a mold for molding;

[0037] Put it into a freeze dryer, freeze at -45°C for 1 hour, pump air at 0°C for 20 hours, and freeze-dry to form a porous anti-adhesion film. Fumigate with 2% glutaraldehyde for half an hour to weakly crosslink. Its area is 20cmX20cm, and its thickness is 0.5mm.

[0038] abdominal surgeryanti-adhesion

[0039] Cut out the size so that the circumference is 0.5-0.8cm larger than the lesion area, and sterilize with ethylene oxide for later use. After removing blood and effusion after the operation, the membrane was pasted on the diseased area, and the...

Embodiment 3

[0041] Preparation of agar and collagen porous anti-adhesion membranes

[0042] The purified agar gel was dissolved in hot water at 90°C with a concentration of 1.0% by weight, and collagen types I and II were swollen in 0.06M acetic acid solution with a concentration of 0.55% by weight;

[0043] The purified agar gel processed in step (1) is mixed with type I and type II collagen according to a mass ratio of 5:1 and poured into a mold for molding;

[0044] Put it into a freeze dryer, freeze at -40°C for 1 hour, pump air at 0°C for 10 hours, and freeze-dry into multiple

[0045] Porous anti-adhesion film. The area of ​​the porous anti-adhesion film is 20cmX20cm, and the thickness is 0.2-0.4mm.

[0046] surgeryanti-adhesion

[0047] The length of the cut is the size of the lesion in the operation area, and the circumference is 1.5-2 times that of the intestine, and it is sterilized with ethylene oxide for later use. After the blood and effusion were removed after the operat...

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PUM

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Abstract

The preparation process of porous antisticking agar-collagen film includes mixing agar and collagen or gelatin and freeze- drying to obtain the antisticking film in 3D porous laminated structure. The porous antisticking agar-collagen film can ensure the nutrient supply essential for tissue to heal, inhibit cell proliferation and make proliferated cell unable to infiltrate healing tissue while degrading to disappear to reach the effect of ensuring tissue healing and preventing tissue proliferation and sticking.

Description

technical field [0001] The invention relates to a biomedical material, in particular to an agar and collagen porous anti-adhesion film and a preparation method thereof. [0002] The invention also relates to the agar and collagen porous anti-adhesion film prepared by the method. Background technique [0003] Adhesion is a protective physiological response of the body to limit the spread of inflammation. Induced by surgical mechanical or chemical damage, interstitial cells and mast cells release a variety of active substances to cause an inflammatory response in the tissue, capillaries penetrate and secrete a large amount of serous fluid. If the serous fluid is not absorbed, fibrin deposits in it, causing fibrin Adhesions occur as cells and capillaries grow in. Clinically, adhesions are often caused by mixed factors, but one or several factors play a major role. It is certain that adhesions are mainly caused by the infiltration of fibroblasts. At present, physical barriers...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10
Inventor 汤顺清
Owner JINAN UNIVERSITY
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