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Antibacterial composite biological material containing agarose acetate and preparation method thereof

A technology of agarose acetate and composite biomaterials, applied in the field of biomedical materials, can solve problems such as undiscovered research or patents, achieve good mechanical properties and biocompatibility, easy operation, and beneficial effects of ecological restoration

Inactive Publication Date: 2018-08-10
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching the literature and related patent databases, no research or patents identical or similar to this research were found

Method used

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  • Antibacterial composite biological material containing agarose acetate and preparation method thereof
  • Antibacterial composite biological material containing agarose acetate and preparation method thereof
  • Antibacterial composite biological material containing agarose acetate and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Embodiment 1: the preparation of composite fiber membrane

[0045] First prepare a mixed solution of agarose acetate (6% mass concentration) and tinidazole (12% mass concentration), the solvent is acetone / N,N-dimethylacetamide (v / v=2:1) . The nanocomposite fiber membrane was prepared by electrospinning (control flow rate was 2.0mL / h, voltage was 20kV, receiving distance was 18cm, humidity was 60%). The prepared nanofibrous membrane was vacuum dried for 24 h and cut into 1.5×1.5 cm 2 The small pieces are sterilized with ethylene oxide for later use. The amplified bone marrow mesenchymal stem cells were planted on the guide membrane, and observed by scanning electron microscope after 7 days of culture, the cells grew well on the scaffold. The antibacterial (Staphylococcus aureus) experimental surface can well inhibit the growth of bacteria.

[0046]The SEM figure of the agarose acetate fiber membrane containing tinidazole that the present embodiment makes, as figure ...

Embodiment 2

[0048] Example 2: Preparation and application of bone conduction fiber membrane containing tinidazole

[0049] Agarose acetate (mass concentration: 6%) and β-tricalcium phosphate (mass concentration: 40%) were prepared, and the solvent was acetone / N,N-dimethylacetamide (v / v=2:1). By electrospinning (control flow rate is 2.0mL / h, voltage is 20kV, receiving distance is 18cm, humidity is 60%) technology, prepare bone conduction fiber membrane; Then prepare agarose acetate (mass concentration is 6%), tinidazole (mass concentration 24%) mixed solution, the solvent is acetone / N,N-dimethylacetamide (v / v=2:1). On the basis of the bone conduction fiber membrane prepared for the first time, the bone conduction fiber containing tinidazole was prepared by electrospinning (control flow rate of 2.0mL / h, voltage of 20kV, receiving distance of 18cm, and humidity of 60%) Then vacuum-dry the obtained fiber membrane for 24 hours, cut into discs with a diameter of 6 mm, and sterilize with ethyle...

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Abstract

The invention discloses an antibacterial composite biological material containing agarose acetate and a preparation method thereof. An antibacterial drug is added to a biologically-inertial agarose acetate electrospun fibrous membrane as a base; hydrogen bonds on the surface of the surface drug of composite fiber can be utilized so that antibacterial particles are firmly supported to the surface of electrospun fiber; therefore, the antibacterial composite biological material containing the agarose acetate is provided. The antibacterial composite biological material can prevent nutrient supplyof healing field tissues from being affected, and normal healing mechanism of the tissues is maintained; during release of the antibacterial drug, the material can degrade and disappear; degradation products never cause toxic and harmful effects to the tissues and the body, and the material can truly promote healing of antibacterial tissues. The antibacterial composite biological material has goodmechanical properties and biological compatibility and has degrading time that matches with healing time of infected tissues; the antibacterial composite biological material is suitable for antibacterial materials, regenerative medical research and clinical practice.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to antibacterial implant materials and technologies, in particular to an antibacterial composite biological material containing agarose acetate and a preparation method thereof. Background technique [0002] The existing antibacterial products mainly include: 1) chitosan; 2) chitosan quaternary ammonium salt; 3) polyester / acrylic acid / sodium iodide ion; 4) silver ion antibacterial dressing; 5) alginate / silver ion. [0003] The research and patent searches related to agarose acetate / antimicrobial composite biomaterials are as follows: [0004] From the Patent Retrieval Database of the State Intellectual Property Office or the Chinese Science and Technology Literature Database, the literature on the use of composite biomaterials with agarose acetate antibacterial agents for antibacterial materials was found, and no report similar to this technology was found. [0005] In foreign lit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/46A61L15/42D04H1/728
CPCA61L15/28A61L15/42A61L15/46A61L2300/404A61L2300/406D04H1/728C08L5/12
Inventor 汤顺清徐遵凯
Owner JINAN UNIVERSITY
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