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Method for preparing injuctable material for repairing bones solidified in situ from calcium alginate

An in-situ solidification, calcium alginate technology, applied in medical science, prosthesis and other directions, to achieve the effect of easy preparation, low pollution and low vacuum

Inactive Publication Date: 2008-12-03
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composition of the material used in this technology has not been reported, and it is a new type of injectable bone repair scaffold material

Method used

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  • Method for preparing injuctable material for repairing bones solidified in situ from calcium alginate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A preparation method of a calcium alginate-based injectable in-situ solidified bone repair material, the preparation steps are as follows:

[0026] Step 1: Take 100 grams of deionized water, add 5 grams of sodium phosphate and 6 grams of sodium alginate powder and stir thoroughly to obtain a sodium alginate solution.

[0027] Step 2: Add 6 grams of nano-hydroxyapatite / collagen (n HAC) particles into the sodium alginate solution in the form of a slurry, and stir well to obtain a viscous suspension.

[0028] Step 3: Add 7 grams of calcium sulfate particles in the form of slurry to the viscous suspension described in Step 2, and stir thoroughly to obtain the calcium alginate-based injectable in-situ solidified bone repair material. It can be molded in situ within 2 hours after being injected into the body.

Embodiment 2

[0030] A preparation method of a calcium alginate-based injectable in-situ solidified bone repair material, the preparation steps are as follows:

[0031] Step 1: Take 100 grams of deionized water, add 5 grams of sodium phosphate and 6.0 grams of sodium alginate powder and stir thoroughly to obtain a sodium alginate solution.

[0032] Step 2: Add 5 grams of nano-hydroxyapatite / collagen (n HAC) particles into the sodium alginate solution in the form of a slurry, and stir well to obtain a viscous suspension.

[0033] Step 3: Add 3 grams of calcium sulfate particles in the form of slurry to the viscous suspension described in Step 2, and stir thoroughly to obtain the calcium alginate-based injectable in-situ solidified bone repair material. It can be molded in situ within 2 hours after being injected into the body.

Embodiment 3

[0035] A preparation method of a calcium alginate-based injectable in-situ solidified bone repair material, the preparation steps are as follows:

[0036] Step 1: Take 100 grams of deionized water, add 1 gram of sodium phosphate and 6 grams of sodium alginate powder and stir thoroughly to obtain a sodium alginate solution.

[0037] Step 2: Add 5 grams of nano-hydroxyapatite / collagen (n HAC) particles into the sodium alginate solution in the form of a slurry, and stir well to obtain a viscous suspension.

[0038] Step 3: Add 7 grams of calcium sulfate particles in the form of slurry to the viscous suspension in step 2, and stir thoroughly to obtain the calcium alginate-based injectable in-situ solidified bone repair material. It can be molded in situ within 2 hours after being injected into the body.

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Abstract

An injectable in-situ-solidifying calcium alginate-based material used for repairing bone is prepared through proportionally mixing deionized water with sodium phosphate powder and sodium alginate powder, stirring, adding the mixture (nHAC) of hydroxy apatite nanoparticles and superfine collagen particles, stirring, adding superfine calcium sulfate particles, and stirring.

Description

technical field [0001] The invention discloses a preparation method of a calcium alginate-based injectable in-situ solidified bone repair material, which belongs to the technical field of preparation methods of biomedical materials. technical background [0002] The preparation methods of injectable bone repair materials are widely used. In the field of biomedical materials, injectable bone repair materials can significantly promote the repair of bone defects. [0003] Injectable bone substitutes currently reported in the literature mainly include: autologous bone marrow and its composites, bone cement, and injectable calcium phosphate materials. Connolly injected autologous bone marrow into the nonunion rabbit animal model and found that the bone marrow had a significant effect on promoting bone healing; Lokiec et al. extracted unilocular bone cyst cyst fluid from 10 patients and injected autologous bone marrow directly into the cavity, and obtained satisfactory curative e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/24A61L27/54
Inventor 冯庆玲谭荣伟甘少磊崔福斋
Owner TSINGHUA UNIV