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Chinese medicine slow-release formulation containing asiatic pennywort herb water-soluble active ingredient, and its preparing method

The technology of a sustained-release preparation and an effective component is applied to the sustained-release preparation of traditional Chinese medicine containing the water-soluble effective component of Centella asiatica and the field of preparation thereof, and can solve the problems of increased toxic and side effects, fluctuation of blood drug concentration, inconvenience for patients to take medicine, and the like, Achieve the effect of delaying release, stabilizing blood concentration and reducing the number of times of medication

Inactive Publication Date: 2008-12-10
ZHEJIANG ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it still has the effects of antidepressant and treating liver and kidney fibrosis
Because the half-life of asiaticosides is relatively short, the common tablets that have been on the market need to be taken 3 times a day, 2-4 tablets each time, which brings inconvenience to the patient's medication, and multiple administrations are more likely to cause blood poisoning. Large fluctuations in concentration, resulting in "peak valley" phenomenon, resulting in increased toxic and side effects

Method used

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  • Chinese medicine slow-release formulation containing asiatic pennywort herb water-soluble active ingredient, and its preparing method
  • Chinese medicine slow-release formulation containing asiatic pennywort herb water-soluble active ingredient, and its preparing method
  • Chinese medicine slow-release formulation containing asiatic pennywort herb water-soluble active ingredient, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh the Centella asiatica extract containing 18g of Centella asiaticoside, 30g of hydroxypropyl methylcellulose, and 50g of microcrystalline cellulose, pulverize respectively, mix, add an appropriate amount of povidone K30 alcohol solution, granulate, dry, Whole grains, added with magnesium stearate, compressed into tablets, ready to be obtained.

[0031] In vitro release:

[0032] The results of in vitro drug release studies of sustained-release tablets are shown in figure 2 : It can be seen from this figure that the two main components of asiaticoside and madecassoside, which are the two main components of asiaticoside and madecassoside, can maintain a slow release. In terms of total glycosides, about 28% are released in the 3rd hour, and the drug is released cumulatively in the 6th hour Around 50%, around 65% at the 9th hour, and 85% at the 12th hour. The release conditions are as follows: according to the Chinese Pharmacopoeia 2000 Edition Part II Release Tes...

Embodiment 2

[0034] Weigh the Centella asiatica extract containing 18g of Centella asiaticoside, 225g of hydroxypropyl methylcellulose, and 50g of microcrystalline cellulose, pulverize respectively, mix, add an appropriate amount of povidone K30 alcohol solution, granulate, dry, Whole grains, add 1 g of magnesium stearate, and compress into tablets.

[0035] In vitro release:

[0036] The results of in vitro drug release studies of sustained-release tablets are shown in image 3 : It can be seen from this figure that the two main components of asiaticoside, madecassoside and madecassoside, can maintain a slow release. In terms of total glycosides, about 15% is released in the 3rd hour, and the drug is released cumulatively in the 5th hour Around 20%, around 38% at the 10th hour, and 45% at the 12th hour. The release conditions are as follows: according to the Chinese Pharmacopoeia 2000 Edition Part II Release Test Method (Blue Method), using water as the dissolution medium, temperature...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine sustained-release preparations, in particular to a water-soluble effective component containing centella asiatica for treating trauma, surgical trauma, burns, keloids and scleroderma, antidepressant and treating liver and kidney fibrosis. Centella glycosides) traditional Chinese medicine slow-release preparation and preparation method thereof. The invention adopts the modern preparation technology to compress the traditional Chinese medicine slow-release preparation with solid medicine, skeleton-type auxiliary materials and other excipients. The solid drug refers to the total glycosides of the water-soluble extract of the traditional Chinese medicine Centella asiatica. The total glycosides contain madecassoside and centella asiatica. The total glycosides content in the extract should not be less than 60%. Skeleton-type excipients mainly refer to hydroxypropyl methylcellulose. By adjusting the amount of excipients in the prescription, the release rate of asiaticoside can be controlled, so as to stabilize the blood concentration of the drug, reduce the frequency of medication, and facilitate the use of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine sustained-release preparations, in particular to a water-soluble effective component containing centella asiatica (centella asiatica) for treating trauma, surgical trauma, burns, keloids and scleroderma, antidepressant and treating liver and kidney fibrosis. Grass glycosides) traditional Chinese medicine slow-release preparation and preparation method thereof. Background technique [0002] In 1847, the German pharmacist Mohr's "Pharmaceutical Technology" announced that pharmacy has become an independent discipline; in the 1960s, people's research on pharmacy has shifted from common pharmaceutical preparations to modern pharmacy, among which Delivery system (drug delivery systems, DDS) is an important research content and development direction of modern pharmacy, including speed controlled release drug delivery system. Hydrophilic gel matrix preparations are representative of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61K9/22A61P17/02A61P1/16A61P25/24
Inventor 王胜浩林芳梁泽华
Owner ZHEJIANG ACAD OF MEDICAL SCI
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