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Ainsliaea fragrans champ extract and preparing method thereof

The technology of apricot fragrant rabbit ear wind and extract is applied in the field of apricot fragrant rabbit ear wind extract and its preparation, which can solve the problems of large daily dosage, low content of active ingredients and high price, reduce the dosage and side effects, and improve the Efficacy of efficacy, safety reagent contamination

Inactive Publication Date: 2009-04-08
上海健坤医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the compounds reported in the literature include sesquiterpene lactones, triterpenoids, organic acids, etc. Xingxiang rabbit ear wind preparations include Xingxiang rabbit ear wind tablets, compound Xingxiang rabbit ear wind granules, etc., all of which are Xingxiang rabbit ear wind The shortcoming of the preparation after simple extraction of wind is that the daily dose is large, the content of active ingredients is low, and the price is high.

Method used

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  • Ainsliaea fragrans champ extract and preparing method thereof
  • Ainsliaea fragrans champ extract and preparing method thereof
  • Ainsliaea fragrans champ extract and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Select 500g of apricot rabbit ear wind medicinal material, cut into sections, put into 1000ml boiling water to kill enzymes, press the stems and leaves into boiling water at any time, wait for 10 minutes after reboiling; add 12 times the amount of water, decoct twice, 1 hour each time, Combine the filtrates; concentrate to 6 times the amount of the original drug, i.e. 3L, centrifuge for 5000r, take the supernatant, put it on a pretreated polystyrene resin column, wash the resin column with 6 times the amount of deionized water until it is nearly colorless, and the flow rate 2BV / h, elute with 30% concentration of ethanol, collect the eluate, reclaim the ethanol under reduced pressure, evaporate to dryness on a water bath, then dry in a vacuum oven and weigh to obtain 6.9g of apricot rabbit ear wind extract, wherein The total flavonoid content is 12%.

Embodiment 2

[0046] Select 500g of apricot rabbit ear wind medicinal material, cut into sections, put into 1000ml boiling water to kill enzymes, press the stems and leaves into boiling water at any time, wait for 10 minutes after reboiling; add 12 times the amount of water, decoct twice, 1 hour each time, Combine the filtrates. Concentrate to 6 times the amount of the original drug, that is 3L, centrifuge 5000r, take the supernatant, put it on a pretreated polystyrene resin column, wash the resin column with 6 times the amount of deionized water until it is almost colorless, and the flow rate is 2BV / h , followed by desorption with more than 85% ethanol, the flow rate is 1BV / h, the amount of ethanol is about 6 times the crude drug amount, the ethanol is recovered under reduced pressure, dried, and the temperature is not higher than 80°C to obtain 14.7g of apricot rabbit ear wind extract, wherein the flavonoid content is 20 %.

Embodiment 3

[0048]Select 10kg of apricot rabbit ear wind medicinal material, cut into sections, put into 20000ml boiling water to kill enzymes, press the stems and leaves into boiling water at any time, wait for 10 minutes after reboiling; add 12 times the amount of water, decoct twice, 1 hour each time, Combine the filtrates. Concentrate to 6 times the amount of the original drug, that is, 60L, centrifuge 5000r, take the supernatant, put it on the resin column that has been pretreated, wash the resin column with 6 times the amount of deionized water until it is almost colorless, the flow rate is 2BV / h, and then use 85 % more than ethanol desorption, flow rate 1BV / h, ethanol consumption about 6 times the crude drug amount, decompression recovery ethanol, drying, temperature not higher than 80 ℃, to get apricot rabbit ear wind extract 300g, wherein the flavonoid content 25%.

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Abstract

The present invention relates to a Chinese medicinal material ainsliaea fragrans extract and its preparation method. Said extract is obtained by using Chinese medicinal material ainsliaea fragrans as raw material. Said preparation method includes the following procedures: 1. inactivating enzyme; 2. coarse extraction; and 3. fine extraction. Beside, said invention also provides the concrete steps of the said every procedure.

Description

technical field [0001] The invention relates to an extract of apricot-flavored rabbit ear wind and a preparation method thereof, belonging to the field of traditional Chinese medicine pharmacy. Background technique [0002] Apricot rabbit ear wind is a commonly used folk herbal medicine. It is the dried whole herb of Ainslia eafragrans champ., a plant of Compositae. It has the effects of clearing away heat and dampness, cooling blood and detoxifying, etc. Symptoms such as edema, carbuncle and swollen poison. It can be used to treat leucorrhea caused by betting of damp heat, manifested as excessive leucorrhea, yellow and sticky; chronic cervicitis sees the above syndromes. Distributed in Jiangsu, Zhejiang, Jiangxi, Fujian, Taiwan, Hunan, Guangdong and other places. It is widely distributed in Jiangxi Province, China, from south to north, and sometimes has a certain advantage in the community (growing in patches), and its rich resources are worthy of development and utilizat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P15/00A61K135/00
Inventor 杜程芳杨明宋浩亮葛卫红梅玲华
Owner 上海健坤医药有限公司
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