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Sambucus Chinensis extract and its preparing method

A technology for extracts and medicinal materials, which is applied to Luying extract and its preparation method and application field in the treatment of hepatitis diseases, can solve the problems of unclear pharmacological action, unclear active ingredients, and difficult quality control, and achieves protection Effects of hepatocytes, improving immunity, reducing dosage and side effects

Inactive Publication Date: 2009-08-26
上海中创医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is aimed at the limitations of the existing viral hepatitis and other liver disease drug treatments, such as easy drug resistance, high recurrence rate, and large side effects, as well as the above-mentioned existing Luying drugs such as simple process, large dosage, and effective ingredients. Unclear, quality is not easy to control, pharmacological effects are not clear, etc., to provide the society with a natural drug Luying extract with clear anti-virus, liver cell protection, and immunity-enhancing effects

Method used

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  • Sambucus Chinensis extract and its preparing method
  • Sambucus Chinensis extract and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: the preparation of Lu Ying extract (1)

[0044] Take 100 grams of Lu Ying medicinal material, add 800 ml liquid extract, add water to make 0.5 g crude drug / ml liquid medicine, stir evenly, filter, and the filtrate is heated and refluxed through polystyrene-type macroporous 75% ethanol for 3 times, each time 1 hours, combined the filtrates, recovered ethanol under reduced pressure, concentrated into a resin column, first eluted with water 5 times the volume of the resin, discarded the water wash, then eluted with 80% ethanol 3 times the volume of the column, collected 80% ethanol to wash Deliquification, concentration under reduced pressure, and vacuum drying at 65° C. yielded 10.4 g of Luying extract, in which the content of ursolic acid was 0.47%.

Embodiment 2

[0045] Embodiment 2: the preparation of Lu Ying extract (2)

[0046] Take 10 kg of Lu Ying medicinal material, add 80 liters of 75% ethanol, heat and reflux extraction for 3 times, each time for 1 hour, combine the filtrate, concentrate under reduced pressure to a relative density of 1.15-1.20 (45°C), add water to make 0.5g Crude drug / ml medicinal solution, filtered after high-speed centrifugation, the filtrate passed through a polystyrene macroporous resin column, first eluted with water 5 times the volume of the resin, then eluted with 70% ethanol 3 times the volume of the column, and collected 70% The ethanol eluate was concentrated under reduced pressure (0.09 MPa, 65° C.) to obtain 945 g of the extract of Lu Ying, in which the content of ursolic acid was 1.7%.

Embodiment 3

[0047] Embodiment 3: the preparation of Lu Ying tablet

[0048] prescription:

[0049] Lu Ying extract 380g, starch 40g, dextrin 60g, sucrose 20g, magnesium stearate 3.6g

[0050] Preparation method: take the extract of Luying prepared in Example 2, add starch, dextrin, sucrose, mix evenly, granulate, dry below 80°C, add magnesium stearate, mix evenly, press into tablets, coat with film, A total of 1000 pieces were produced.

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Abstract

The present invention relates to an extract of Rhizoma Rhizoma and a preparation method thereof. The extract of Rhizoma Rhizome of the present invention is prepared by the following method, and the preparation method includes the following steps: (1) extracting the medicinal material of Rhizoma Rhizome with a solvent, and then concentrating it to obtain Extract; (2) The extract in step (1) is absorbed and eluted to obtain the extract.

Description

technical field [0001] The invention relates to a natural plant extract and a preparation method thereof, in particular to an extract of Lu Ying, a preparation method thereof and an application in the treatment of hepatitis diseases. Background technique [0002] Viral hepatitis is a malignant infectious disease with a high incidence rate, among which hepatitis B has the highest incidence rate and spreads all over the world. my country is a high incidence area of ​​hepatitis B virus, and there are about 120 million hepatitis B virus carriers. Hepatitis B can lead to various types of liver diseases such as chronic hepatitis, liver cirrhosis and primary liver cancer, which seriously endanger human health. Currently, drugs for the treatment of hepatitis B mainly include α-interferon and lamivudine for virus replication, as well as immunomodulators for adjuvant therapy, symptomatic treatment, and liver protection drugs. α-interferon is an anti-hepatitis B virus drug with relati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/35A61P1/16A61P31/14A61K133/00
Inventor 刘江云杨明宋浩亮葛卫红梅玲华刘铜华
Owner 上海中创医药科技有限公司
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