Compound 2,3,4,6,8-pentamethoxyl-dibenzofuran and its use

A pentamethoxy, diphenyl technology, applied in the field of natural medicinal chemistry, can solve problems such as toxicity, and achieve significant social and economic benefits.
CN100486971CActive Publication Date: 2009-05-13BEIJING INSTITUTE OF TECHNOLOGYGY +1

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING INSTITUTE OF TECHNOLOGYGY
Publication Date
2009-05-13

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Abstract

The present invention discloses new type of compounds 2, 3, 4, 6, 8-pentamethoxyl-dibenzofuran extracted from haw root and its medicinal use. These compounds have activity of inhibiting semicarbazide sensitive amine oxidase (SSAO). The raised activity of SSAO is related with several kinds of serious diseases, and in the case of existing transition metal, the deaminated products of SSAO, formaldehyde and hydrogen peroxide, will generate free radicals, the accumulation of which may result in oxidizing damage to human body and cause diseases, such as stress ulcer, atherosclerosis, heart disease, malignant tumor, etc.
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Description

Technical field:

[0001] The present invention relates to 2,3,4,6,8-pentamethoxy-dibenzofuran and its use, in particular to the new compound 2,3,4,6,8-5 extracted and isolated from natural plants Methoxy-dibenzofuran and its use in inhibiting the activity of semicarbazide-Sensitive Amine Oxidase (SSAO enzyme, Semicarbazide-Sensitive Amine Oxidase) belong to the field of natural medicinal chemistry. Background technique:

[0002] 1. Research progress of natural products

[0003] What the present invention researches is the root of Hawthorn, a plant of the Rosaceae Hawthorn genus. Hawthorn is distributed in the northern temperate zone, and there are more than 280 species of this genus in the world. Its fruit is a commonly used traditional Chinese medicine. According to the "Compendium of Materia Medica": this product is "sweet and sour, warm in taste, relieves food accumulation, and nourishes the spleen". It is cultivated all over the country and is a homologous plant for me...

Claims

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