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Filming gel composition and its use

A gel composition and film-forming technology, applied in the direction of drug combinations, medical preparations of non-active ingredients, blood diseases, etc., can solve problems such as shedding, fast disappearance, unfavorable gels closely arranged, etc., and achieve good flexibility Effect

Active Publication Date: 2009-06-17
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear, and its effective residence time on the oral mucosa is only 3 to 4 hours
The reason for the shorter residence time of the film may be related to the following reasons: (1) there are only two hydroxyl groups that can provide crosslinking on the monolaurin monoglyceride, and there are fewer crosslinkable sites; (2) monoglyceryl laurate The longer carbon chain structure (12-carbon alkyl chain) in the oil molecule may shield part of the crosslinking sites, and the longer carbon chain of lauric acid is not conducive to the tight arrangement inside the gel
These factors weaken the cohesive forces within the gel, causing the film to rupture, dissolve and / or erode more easily, resulting in a faster disappearance

Method used

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  • Filming gel composition and its use
  • Filming gel composition and its use
  • Filming gel composition and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 16～21

[0047] Table 2

[0048]

[0049] With benzocaine (Benzocaine), triamcinolone acetonide (Triamcinolone Acetonide), nitrate (Econazole Nitrate), amlexanox (Amlexanox) and chlorhexidine acetate (Chlorhexidine Acetate) as model drugs, the 100 grams of drug film-forming gel compositions were prepared respectively according to the preparation method in Example 1, wherein the drug was added to the solvent together with the esterifying agent.

[0050] The pharmaceutical film-forming gel composition prepared in Table 2 is a translucent semi-solid gel in appearance and has an ethanol smell, and can form a smooth, tough, wear-resistant, and durable hydrophobic film on the skin or mucous membrane.

[0051] The various component raw materials in the foregoing examples are conventional commercially available products.

Embodiment 19

[0067] The samples of the triamcinolone acetonide / econazole nitrate film-forming gel composition of embodiment 19, the chlorhexidine acetate film-forming gel composition of embodiment 21, Zilactin-B, USP Gel carried out rat skin adhesion performance, erosion Comparison of conditions and length of stay.

[0068] Divide 16 experimental rats into 4 groups at random, 4 in each group, cut off the hair on the back of the rat and shave the fine hair on the surface with a razor, disinfect with alcohol, and after drying, apply a thin layer to the 4 samples respectively Applied on the treated skin in the same way, all 4 samples can form a layer of adhesive film. Observe the adhesive properties, erosion conditions and residence time on the skin (based on the disappearance of 1 / 2 of the film area) of the film. The results are shown in Table 5.

[0069] Table 5. Comparison of skin adhesion performance, erosion phenomenon and residence time

[0070] sample Adhesive properties ...

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Abstract

The present invention belongs to the field of one kind of filming gel composition and its use. The filming gel composition contains hydroxyalkyl cellulose, esterifying agent, crosslinking agent and solvent. The crosslinking agent is saturated fatty polyol or alcohol acid in the chemical general expression of CnH2n+2-m-l(OH)m(COOH)l, where n, m and l are integrals, n is not smaller than m, m is not smaller than 2, l is not smaller than 0, m+l is 4-8 and n+l is 4-8. The present invention also discloses the application of the filming gel composition as medicine carrier to form medicine gel composition capable of forming smooth, tough, antiwear, lasting and hydrophobic film, and the film may be retained in oral mucosa for over 5 hr or on skin for over 8 hr.

Description

technical field [0001] The invention relates to a film-forming gel composition and its application, and a drug film-forming gel composition made from the film-forming gel composition as a drug carrier. Background technique [0002] Human skin, oral mucosa damage caused by cuts, abrasions, incisions and burns; inflammation caused by bacterial, fungal or viral infection; ulcers caused by various reasons and pain in local tissues caused by various reasons, etc. Common diseases that people often encounter in daily life. The topical pharmaceutical preparations clinically used to treat skin and oral mucosal diseases are usually creams, ointments, gels, tinctures, pastes, gargle sprays, etc., when these preparations are applied on human tissues or oral mucosa During local treatment, due to the normal activities of the affected area and its surrounding tissues, such as friction, sweat, saliva secretion and flushing, these agents will dissolve and / or erode, shift, and fall off, and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L1/26C08J3/075C08K5/04A61K47/36A61P23/00A61P7/04
Inventor 马晋隆陈志明倪旻
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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