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Medicine composition containing bailobalide

A technology of ginkgolides and medicines, applied in the field of pharmaceutical compositions, can solve problems such as no practical use

Active Publication Date: 2009-07-29
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So there is basically no practical possibility

Method used

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  • Medicine composition containing bailobalide
  • Medicine composition containing bailobalide
  • Medicine composition containing bailobalide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] Prescription (in 1000 dosage units):

[0131]

[0132] Preparation

[0133] Take about 80% of the prescribed amount of water for injection, the prescribed amount of glycerin and ethanol, put it in the liquid tank, add the prescribed amount of ginkgolide, stir to dissolve, add water for injection to the full amount, adjust the pH with 10% citric acid solution, Stir well, after the semi-finished product passes the inspection, use the 0.65μm and 0.45μm composite alcohol-resistant microporous filter membrane as the filter material to filter and clarify the micromembrane filtration system, fill it in a 5ml glass bottle, sterilize at 100°C for 20 minutes, cool, Light inspection, labeling, that is.

[0134] Content Determination High performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) was used to directly determine the content of ginkgo terpenoid lactones A, B, C and bilobalide in ginkgo leaves. Method: 10% methanol was used to prepare the...

Embodiment 2

[0137] Prescription (in 1000 dosage units):

[0138]

[0139] Preparation

[0140] Take about 80% of the prescribed amount of water for injection, the full amount of glycerin and ethanol prescribed, put it in a liquid tank, add the prescribed amount of ginkgolide, stir to dissolve, add water for injection to the full amount, adjust the pH with 10% acetic acid solution, stir Uniform, semi-finished products pass the inspection, use 0.65μm and 0.45μm composite alcohol-resistant microporous membranes as filter materials for micro-membrane filtration system to filter and clarify, fill in 2ml glass bottles, sterilize at 100°C for 20 minutes, cool, and light Check, label, and get it.

[0141] Content Determination High performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) was used to directly determine the content of ginkgo terpenoid lactones A, B, C and bilobalide in ginkgo leaves. Method: 10% methanol was used to prepare the test solution, and pa...

Embodiment 3

[0144] Prescription (in 1000 dosage units):

[0145]

[0146] Preparation

[0147] Take about 80% of the prescribed amount of water for injection, the prescribed amount of glycerin and ethanol, put it in the liquid tank, add the prescribed amount of ginkgolide, stir to dissolve, add water for injection to the full amount, adjust the pH with 10% citric acid solution, Stir well, after the semi-finished product passes the inspection, use a 0.65μm and 0.45μm composite alcohol-resistant microporous filter membrane as the filter material to filter and clarify the micromembrane filtration system, fill it in a 2ml glass bottle, sterilize at 100°C for 20 minutes, cool, Light inspection, labeling, that is.

[0148] Content Determination High performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) was used to directly determine the content of ginkgo terpenoid lactones A, B, C and bilobalide in ginkgo leaves. Method: 10% methanol was used to prepare the t...

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PUM

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Abstract

The present invention discloses one kind of bailobalide injection, and the bailobalide injection has certain ratio of bailobalide and high long-term stability. The bailobalide injection can maximize the effects of bailobalide in promoting nerve growth, preventing demyelinization of brain and spinal nerve, and preventing the occurrence and development of senile dementia.

Description

technical field [0001] The invention relates to a ginkgolide-containing preparation, in particular to a ginkgolide injection, and also provides a preparation process of the injection, which belongs to the field of pharmaceutical compositions. Background technique [0002] Ginkgolide is an effective substance extracted from the leaves of the Chinese herbal medicine Ginkgo biloba. Ginkgolide is a diterpene compound, which includes 1 tetrahydrofuran ring, 3 r-lactone groups and 2 pentacarbon rings linked in 1 The spiro[4,4]nonane system formed on the carbon atom, a unique C20 caged molecule with a total of 6 pentacarbon rings combined with tert-butyl. Its cis-fused rings F, A, D and C are shaped into a hemispherical cavity, which is enough to accommodate a cation or a positively polarized organic molecule. [0003] P.Braquet et al. (1988) report that known ginkgolides have 5 kinds, with A, B, C, M, J name (Ginkgolides A, B, C, M, J), the basic structure of ginkgolides is commo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/08A61K9/107A61K9/20A61K9/22A61K9/48A61K9/14A61P9/10A61P7/02A61P25/28
Inventor 孙毅
Owner CHENGDU BAIYU PHARMA CO LTD