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New pranoprofen eye drops and its preparation method

A technology of eye drops and aqueous solutions, applied in the field of medicine, can solve the problems of unseen pranoprofen eye drops, etc., and achieve stable and reliable storage effects

Active Publication Date: 2009-08-05
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Domestic pranoprofen eye drops have been listed, but there is no report of pranoprofen eye drops with sodium hyaluronate

Method used

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  • New pranoprofen eye drops and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Pranoprofen 1g

[0020] Sodium Hyaluronate 1g

[0021] Appropriate amount of related accessories

[0022] Add water for injection to 1000ml

[0023] Preparation method:

[0024] Get pranoprofen and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0025] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0026] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

Embodiment 2

[0028] prescription:

[0029] Pranoprofen 1g

[0030] Sodium Hyaluronate 1g

[0031] Boric acid 15g

[0032] Appropriate amount of related accessories

[0033] Add water for injection to 1000ml

[0034] Preparation method:

[0035] Get pranoprofen, boric acid and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0036] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0037] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

Embodiment 3

[0039] prescription:

[0040] Pranoprofen 1g

[0041] Sodium Hyaluronate 2g

[0042] Boric acid 15g

[0043] Appropriate amount of related accessories

[0044] Add water for injection to 1000ml

[0045] Preparation method:

[0046] Get pranoprofen, boric acid and related auxiliary materials and dissolve in appropriate amount of water for injection respectively.

[0047] Take the prescribed sodium hyaluronate in water for injection, stir continuously at 60-70°C to make it fully swell, boil, and filter while hot with a microporous membrane.

[0048] Slowly add the filtered sodium hyaluronate solution into the pranoprofen solution, stir evenly while adding, add water for injection to a sufficient amount, filter to obtain a clear solution, subpackage, and inspect the quality to complete.

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Abstract

The invention discloses a new pranoprofen eye drop and a preparation method thereof. The preparation method of the new pranoprofen eye drops of the present invention is: after pranoprofen and related adjuvant are dissolved in water, the aqueous solution that has swelled sodium hyaluronate is added in the medicinal liquid, stir evenly, add water to enough Measure, filter, sub-package, and get it. The invention provides a new pranoprofen eye drop and a preparation method thereof, which basically overcomes the defects of the existing pranoprofen eye drop. Sodium hyaluronate prolongs the life of the drug through physical thickening and moisturizing and lubricating effects. During the residence time on the ocular surface, the medicine is not easy to flow into the mouth and nasal cavity. First, the loss of the medicine is reduced. Second, the bitter taste of the pranoprofen eye drops is overcome, the compliance of the patient is improved, and the clinical efficacy is ensured.

Description

technical field [0001] The invention relates to the technical field of medicine, and discloses a new pranoprofen eye drop and a preparation method thereof. Background technique [0002] Pranoprofen, chemical name: 2-(5H-[1]benzopyran[2,3-b]pyridin-7-yl)propionic acid, structural formula is as follows: [0003] [0004] Prostaglandins have a wide range of local effects on various tissues, especially when inflammatory reactions occur, they can be found in various animals and human bodies, and are relatively important substances in inflammatory reactions. Physical and chemical trauma to the eye, surgery, anterior chamber puncture, laser irradiation, and stimulation of the trigeminal nerve all lead to the synthesis and release of prostaglandins in ocular tissues, resulting in miosis, conjunctival and vasodilation, increased aqueous humor protein content, and increased intraocular pressure. Glucocorticoids are effective drugs to control non-infectious inflammation of the oute...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/436A61K9/08A61P27/02
Inventor 张宏业
Owner JIANGSU JIBEIER PHARMA
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