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Jingangteng solution type solid dispersion, and application

A solid dispersion and solution type technology, which is applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve the problems of slow dissolution rate of active ingredients, unsatisfactory curative effect, poor absorption, etc. Accurate, beneficial to labor protection, and the effect of reducing environmental pollution

Inactive Publication Date: 2009-08-19
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the preparation products currently on the market are mainly syrups, and there are also tablets, capsules, granules, etc., due to the slow and incomplete dissolution rate of active ingredients, resulting in poor absorption and unsatisfactory curative effect, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of King Kong Vine Extract:

[0030] Soak the Vajra vine with 5 times the amount of 75% ethanol for 24 hours, heat and reflux for extraction 3 times, 1 hour each time, combine the extracts, filter, concentrate the filtrate, vacuum dry, and pulverize into fine powder to obtain.

Embodiment 2

[0032] Add 100 grams of Vajra vine extract, 80 to 120 grams of polysorbate, to 280 grams of molten poloxamer, mix, stir evenly, heat to dissolve, degas, cool to 45°C, and then fill with a capsule liquid filling machine 1000 capsules, the extract content of Vajra vine extract is 0.1 g / capsule.

Embodiment 3

[0034] After moistening 200 grams of Vajra vine extract with 100 grams of polysorbate 20, add it to 200 grams of molten polyvinylpyrrolidone, mix, stir evenly, heat to dissolve, degas, cool to 45°C and fill with capsule liquid 1000 capsules are machine-filled, and the extract content of diamond vine is 0.2 g / capsule.

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PUM

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Abstract

The invention discloses a solution-type solid dispersion of rambutan and its application. The components and the weight content include: 20-60% of the extract of the rambutan, 5-40% of the solubilizer, and 20-75% of the carrier. The Jingangteng solution-type solid dispersion of the present invention can avoid the flying of drug dust, is convenient for filling, and is not easy to oxidize and absorb moisture. The test results show that the Jingangteng capsule of the present invention has good dissolution performance, and the dissolution speed and degree are significantly increased, indicating that it has Fast absorption and high bioavailability.

Description

Technical field [0001] The invention relates to a diamond vine preparation. Background technique [0002] Jingangteng is the rhizome of Smilax in the Liliaceae family. It has the effects of clearing away heat, detoxifying, reducing swelling and dispelling lumps. It is mainly used clinically to treat adnexitis, adnexa inflammatory mass and various gynecological inflammations in the lower abdomen, low back pain, and menstrual irregularities. It is also used to treat rheumatic joint pain, bruises, cellulitis, gastroenteritis and so on. [0003] However, the current preparations on the market are mainly syrups, as well as tablets, capsules, granules, etc. Due to the slow and incomplete dissolution rate of the active ingredients, poor absorption and unsatisfactory curative effects are caused. Summary of the invention [0004] The purpose of the present invention is to provide a diamond solution type solid dispersion and its application to overcome the above-mentioned drawbacks. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K9/48A61P29/00A61P15/00A61P19/02A61P1/04
Inventor 顾林金沈航孝
Owner SHANGHAI INST OF PHARMA IND CO LTD