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Chloromycetin solution for eye and preparation method thereof

An ophthalmic solution and chloramphenicol technology are applied in the field of chloramphenicol ophthalmic solution and its preparation, and can solve the problems of only one year of shelf life and unfavorable use by patients.

Inactive Publication Date: 2009-10-28
张咏梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1872038A has introduced drop pill type chloramphenicol eye drops and preparation method thereof, and it isolates chloramphenicol and aqueous solution by preparing main drug chloramphenicol into drop pills, thereby reaching the purpose of extending the period of validity of the drug, but due to The solubility of chloramphenicol in water is slightly soluble. When the above-mentioned drugs are used, they must be shaken for a long time to dissolve chloramphenicol, which is not conducive to the use of patients.
[0004] Chinese patent CN1163266C discloses a kind of eye drops for the treatment of conjunctivitis and keratitis eye disease, it improves its anti-staphylococcus aureus, escherichia coli sterilization rate, but the shelf life of the above products can only reach one year

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.1 grams of rosemary extract, add water to 1000 milliliters, and the pH value of the solution is 6.3.

Embodiment 2

[0032] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.3 grams of rosemary extract, and add water to 1000 milliliters.

Embodiment 3

[0034] Take 2.5 grams of chloramphenicol, 1.5 grams of boric acid, 0.5 grams of borax, 6.5 grams of sodium chloride, and 0.5 grams of rosemary extract, and add water to 1000 milliliters.

[0035] Embodiment 1 result is as shown in table 1:

[0036] Table 1:

[0037] 4 months accelerated

[0038] Embodiment 2 result is as shown in table 2:

[0039] Table 2:

[0040] 4 months accelerated

[0041] Embodiment 3 results are as shown in table 3:

[0042] table 3:

[0043] 4 months accelerated

[0044] p-nitrobenzaldehyde content (%)

[0045] Examples 1-3 show that when the content of rosemary extract is 0.01-0.05%, the present invention can be realized.

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PUM

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Abstract

The invention discloses a chloramphenicol ophthalmic solution, which comprises chloramphenicol and a buffer solution. The solution contains rosemary extract with a weight concentration of 0.01-0.05%. The chloramphenicol ophthalmic solution of the invention can be Prepare according to the existing production process, and also can prepare according to the following method. The preparation method of the present invention includes a preparation process and a potting process. Compared with the prior art, the present invention has a shelf life of more than 2 years, which is beneficial to The production, sales and use of chloramphenicol ophthalmic solution have great benefits for creating an economical society.

Description

technical field [0001] The invention belongs to a chloramphenicol eye solution and a preparation method thereof, in particular to a chloramphenicol eye solution containing rosemary extract and a preparation method thereof. Background technique [0002] Chloramphenicol Ophthalmic Solution, also known as Chloramphenicol Eye Drops, is a commonly used drug for the eyes. It is a drug included in the second part of the 2005 edition of the Chinese Pharmacopoeia. It was once circulated in the market as an OTC Class A drug Its main components are chloramphenicol, buffer, bacteriostat, water, and sodium hyaluronate and glycerin are also added to chloramphenicol eye drops to enhance the viscosity and improve the retention time in the eyes. The usual shelf life of medicines is 2 years, but the shelf life of chloramphenicol eye drops can only reach 8-12 months, this is because chloramphenicol in chloramphenicol eye drops is easily decomposed into chloramphenicol Nitrobenzaldehyde, chlor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/46A61K47/22A61K31/165A61K9/08A61P27/02
Inventor 张咏梅
Owner 张咏梅