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Novel use of Enduotai, hard capsule thereof, and method for preparing the injection

A technology of hard capsules and injections, which is applied in the field of medicine and can solve problems affecting wide application

Inactive Publication Date: 2007-07-18
王广笙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These factors have affected its wide application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Tumor suppression experiment EDT has obvious killing effect on giant cell carcinoma of the lung PLA-801: when the concentration of EDT is 5 and 10mg / L, the effect is 32h, and its killing rate is 76.8 and 87.5% respectively, see Table 1

[0017] The inhibitory rate % of table 1 EDT to human lung giant cell carcinoma PLA-801 cell

[0018] Concentrationmg / L

Embodiment 2

[0019]Example 2 Clinical observation 12 patients with advanced lung cancer, 8 males and 4 females, aged 45-68 years, with an average of 50.6 years old, no chance of surgical treatment, all cases were selected through clinical B-ultrasound, CT, chest X-ray, biochemical, etc. Check confirmed cases. He has not received anti-cancer treatment for nearly a month, and the estimated survival period may be 2 months. Oral EDT tablets (5 tablets each), gradually increased from 1 tablet each time to 10 tablets, 3 times a day, for 2 months. It can be seen that the patient's condition was stable and the symptoms were relieved: 7 cases of 13 cases of loss of appetite had increased food intake to varying degrees; 7 cases of 13 cases of abdominal distention were relieved; The body temperature of the fever patients all fell below 37.5°C; 11 cough patients had relief to varying degrees; 7 cases of bloody sputum once decreased; Such patients with advanced lung cancer often died due to upper gas...

Embodiment 3

[0020] Example 3 Clinical observation 2 female patients with advanced lung cancer, 1 case, Liu, was treated in Beijing China-Japan Hospital, took EDT tablets 20mg / time, 3 times a day, and cooperated with traditional Chinese medicine treatment, and the survival period was more than 6 years; One case, Yang, took EDT tablets for a long time and did not cooperate with traditional Chinese medicine treatment. His condition was stable, his survival period was more than 7 and a half years, and he participated in certain social activities. Some of the above patients had nausea, diarrhea and other gastrointestinal reactions, which could be relieved by reducing the dose, but none of them had toxic reactions to the heart, liver, kidney and blood.

[0021] 1.2 Treatment of bowel cancer

[0022] Example 1 Tumor inhibition experiment Nude mice were divided into control group and experimental group, 3 groups in total, 5 mice in each group. Nude mice were subcutaneously inoculated with human ...

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PUM

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Abstract

An application of Endothal (EDT or norcantharidine) in preparing capsule or injection for treating lung cancer, intestinal cancer, breast cancer, leukemia, ovary cancer, etc is disclosed. Its preparing process and content measuring method are also disclosed.

Description

[0001] 1. New uses of endotai technical field [0002] The present invention relates to medicines, that is, to increase new indications of already used chemotherapeutic drugs. Background technique [0003] 1. Basic profile Compound appearance-7-oxabicyclo[2.2.1]heptane-2.3-dicarboxylic anhydride, molecular formula C 8 h 8 o 4 , molecular weight 168.15. In the 1940s, it was used as a herbicide and cotton defoliant in agriculture abroad, and the name was Endothal. It was first used as a clinical medicine in China, called norcantharidin. (for avoiding to confuse with poisonous Chinese medicine Mylabris title, be convenient to clinical application, the Chinese name that uses in the present invention is " Endotai ", be called for short EDT). EDT has tablet (5mg / tablet) and injection (10mg / 2ml). It has been used to treat liver cancer, esophageal cancer, gastric cancer, low white blood cell (WBC), and hepatitis, cirrhosis, and hepatitis B virus co-carriers. [0004] Studies ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K9/48A61K9/08A61P35/00
Inventor 王广笙
Owner 王广笙