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Degradable shell used for medicine releasing capsule and its preparation technology

A technology of electronic capsules and shells, applied in capsule delivery, drug devices, applications, etc., can solve the problems of large clinical use risks and invariance, and achieve the effect of improving clinical safety.

Inactive Publication Date: 2007-07-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the problem with the current technical solution is that the shape of the electronic capsule remains unchanged during the process of passing through the entire digestive tract, and the fact that the electronic capsule can be swallowed does not mean that the capsule can be smoothly discharged. If there is an obstruction somewhere in the tract, the electronic capsule can only be removed by surgery, or even by laparotomy. Therefore, the current technical solution has a large risk of clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] This embodiment provides a degradable shell for the electronic capsule of drug release. There is a through hole that can be opened on the shell, and a sealing plug is arranged in the through hole. The drive of the electronic capsule for drug release can be encapsulated in the shell. After the drug release action is carried out, the sealing plug in the through hole is disengaged, and the shell support in the present implementation includes the following components and mass percentages: ethyl cellulose=65%, barium sulfate developer=10%, sodium hydroxymethyl starch= 25%, the shell coating is medical grade paraffin.

[0017] The preparation process for the degradable shell of the drug-releasing electronic capsule in this embodiment is carried out according to the following sequence steps:

[0018] 1. Prepare the shell support material: according to the quantity of the shell support to be prepared, weigh the shell support material according to the mass ratio of ethyl cellulo...

Embodiment 2

[0023] This embodiment provides a degradable shell for the electronic capsule of drug release. There is a through hole that can be opened on the shell, and a sealing plug is arranged in the through hole. The drive of the electronic capsule for drug release can be encapsulated in the shell. After the drug release action is carried out, the sealing plug in the through hole is separated, and the shell support in this implementation includes the following components and mass percentages: cellulose cerate=70%, barium sulfate developer=15%, cross-linked polyvinylpyrrolidone= 15%, the shell coating is medical grade paraffin.

[0024] The preparation process for the degradable shell of the drug-releasing electronic capsule in this embodiment is carried out according to the following sequence steps:

[0025] 1. Prepare the shell support material: according to the quantity of the shell support to be prepared, weigh the shell support material according to the mass ratio of cellulose cera...

Embodiment 3

[0030] This embodiment provides a degradable shell for the electronic capsule of drug release. There is a through hole that can be opened on the shell, and a sealing plug is arranged in the through hole. The drive of the electronic capsule for drug release can be encapsulated in the shell. After the drug release action is carried out, the sealing plug in the through hole is separated. The shell support in this implementation includes the following components and mass percentage: it is characterized in that the shell support includes the following specific components and mass percentage: high viscosity hydroxypropyl cellulose =75%, barium sulfate developer=10%, low-substituted hydroxypropyl cellulose=15%, and the shell coating is medical grade paraffin.

[0031] The preparation process for the degradable shell of the drug-releasing electronic capsule in this embodiment is carried out according to the following sequence steps:

[0032] 1. Prepare shell support material: accordin...

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PUM

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Abstract

A degradable casing for the medicine-releasing electronic capsule has an openable through hole with a sealing plug in it, and is prepared from medicinal material difficult to dissolve (60-80 mass%), X-ray developer (10-20) and disintegrant (10-30). Its coated layer is prepared from medical paraffin wax.

Description

Technical field: [0001] The invention relates to a degradable shell for drug-releasing electronic capsules and a preparation process thereof. Background technique: [0002] Drug-release electronic capsule is a drug release system based on micro-mechanical electronic technology. It can control the release time and location of drugs in the digestive tract through remote control outside the body. It has good application value in clinical treatment and drug absorption research in the digestive tract. In Chinese patents CN200410040809.3 and ZL02128141.6, the schemes of drug-releasing electronic capsules are disclosed. The shells of current drug-releasing electronic capsules are generally made of materials such as plastics or stainless steel with good biocompatibility, and their common characteristics are good strength and corrosion resistance, that is, they cannot be degraded in the digestive tract. Ensure that the electronic components in the electronic capsule do not come into...

Claims

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Application Information

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IPC IPC(8): A61M31/00A61D7/00A61B5/06A61K9/48A61J3/07A61L31/14A61L31/00
Inventor 皮喜田梅虎刘洪英张海燕师小荃赵素文林玉琳
Owner CHONGQING UNIV