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Method for preparing polyferose

A technology of polysaccharide iron and water iron, which is applied in the field of polysaccharide iron production and can solve the problems of methanol toxicity

Inactive Publication Date: 2007-07-25
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the process uses methanol as a precipitant, but methanol is more toxic, and a less toxic precipitant should be used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] At room temperature, 360 grams of ferric chloride hexahydrate and 750 grams of water were added into the reactor to dissolve into an aqueous solution of ferric chloride. Adding reduction value DE is 780 grams of oligosaccharide syrup of 71%, and the solid sugar content of oligosaccharide syrup is 26.5%. Stir, and continuously and uniformly add a sodium carbonate aqueous solution with a concentration of 0.2 (W / W) until Fe(OH) is generated 3 Precipitation, the solution is still acidic at this time. The feeding time of the aqueous sodium bicarbonate solution was 35 minutes. After stirring for 15 minutes, within 20 minutes, a sodium hydroxide aqueous solution with a concentration of 0.3 (W / W) was continuously and uniformly added until the pH value of the solution was 11.6. The temperature of the reaction kettle was raised to make the temperature of the reaction solution reach 81° C., and after keeping for 20 minutes, the reaction solution was cooled to room temperature. ...

Embodiment 2

[0017] At 10°C, add 18 kg of ferric chloride hexahydrate and 45 kg of water into the reaction kettle to dissolve into an aqueous solution of ferric chloride. Adding reduction value DE is 39 kilograms of oligosaccharide syrup of 69%, and the solid sugar content of oligosaccharide syrup is 26.1%. Stir, and continuously and uniformly add a sodium carbonate aqueous solution with a concentration of 0.3 (W / W) until Fe(OH) is generated 3 Precipitation, the solution is still acidic at this time. The feeding time of the aqueous sodium bicarbonate solution was 45 minutes. After stirring for 20 minutes, within 25 minutes, a sodium hydroxide aqueous solution with a concentration of 0.3 (W / W) was continuously and uniformly added until the pH value of the solution was 11.6. The temperature of the reaction kettle was raised to make the temperature of the reaction solution reach 78° C., and after keeping for 20 minutes, the reaction solution was cooled to room temperature. The reaction sol...

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Abstract

This invention discloses a process for preparing polyferose from oligosaccharides, lye and ferric salt. The method operates at a water / iron weight ratio above 3.5, and adds lye by flow addition. Besides, the method adopts ethanol as the precipitant and low-speed centrifuge to separate and purify the product. Polyferose can be used to treat iron deficiency anemia, and has such advantages as good iron-supplement effect, and few gastroenteric side effects.

Description

1. Technical field [0001] The invention relates to a process for producing polysaccharide iron by using ferric iron, oligosaccharide and alkali as raw materials, and belongs to the technical field of medicine synthesis. 2. Background technology [0002] Polysaccharide iron is a complex of oligosaccharides and ferric iron, which is used to treat iron deficiency anemia, and the iron content in polysaccharide iron is 40-46%. The polysaccharide iron has high iron element content, good iron supplement effect and low production cost. Polysaccharide iron is completely absorbed in molecular form, and polysaccharide iron does not contain free iron ions, so polysaccharide iron has little side effects on the gastrointestinal tract, and has no side effects such as nausea, abdominal pain, and diarrhea. [0003] The main way to treat iron deficiency anemia is to supplement the body with sufficient iron. Existing medicines for the treatment of iron deficiency anemia are mainly divalent i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00
Inventor 刘均洪邱龙辉张媛媛叶琳杨丰科王繁业吴汝林孙岩
Owner QINGDAO UNIV OF SCI & TECH
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