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Compound sarafloxacin hydrochloride injection, preparing method and use thereof

A technology of sarafloxacin hydrochloride and injection, which is applied in medical formula, medical preparations containing active ingredients, drug delivery, etc. It can solve the problems of weakened effect of common drugs and drug resistance of virus strains, and achieve rapid diuretic effect and biological The effect of high utilization rate and wide clinical application

Inactive Publication Date: 2007-08-15
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For a long time, due to the overuse of antibiotics, virus strains have become more and more resistant, and common drugs have gradually become less effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 (every portion is 500g)

[0018] Compound sarafloxacin hydrochloride injection: 13 parts of sarafloxacin hydrochloride, 1 part of furosemide, 120 parts of propylene glycol, 120 parts of ethanol

[0019] Made in the following way:

[0020] (1) Get 13 parts of sarafloxacin hydrochloride, 1 part of furosemide, 120 parts of propylene glycol, and 120 parts of ethanol by weight;

[0021] (2) Add the sarafloxacin hydrochloride to 30 parts of water for injection, add an appropriate amount of ethanolamine and stir until fully dissolved;

[0022] (3) described propylene glycol, ethanol are mixed and stirred evenly;

[0023] (4) Combine the solution prepared by step (2) and step (3) and stir evenly; adjust the pH to 9.5-11 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts, and then make a compound sarafloxacin hydrochloride Injection.

Embodiment 2

[0024] Embodiment 2 (every portion is 1500g)

[0025] Compound sarafloxacin hydrochloride injection: 5 parts of sarafloxacin hydrochloride, 1.5 parts of furosemide, 50 parts of propylene glycol, and 500 parts of ethanol.

[0026] Made in the following way:

[0027] (1) Get 5 parts of sarafloxacin hydrochloride, 1.5 parts of furosemide, 50 parts of propylene glycol, and 50 parts of ethanol by weight;

[0028] (2) Add the sarafloxacin hydrochloride to 30 parts of water for injection, add an appropriate amount of ethanolamine and stir until fully dissolved;

[0029] (3) described propylene glycol, ethanol are mixed and stirred evenly;

[0030] (4) Combine the solution prepared by step (2) and step (3) and stir evenly; adjust the pH to 9.5-11 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts, and then make a compound sarafloxacin hydrochloride Injection.

Embodiment 3

[0031] Embodiment 3 (every portion is 500g)

[0032] Compound sarafloxacin hydrochloride injection, 20 parts of sarafloxacin hydrochloride, 5 parts of furosemide, 300 parts of propylene glycol, and 300 parts of ethanol.

[0033] Made in the following way:

[0034] (1) Get 20 parts of sarafloxacin hydrochloride, 5 parts of furosemide, 300 parts of propylene glycol, and 300 parts of ethanol by weight;

[0035] (2) Add the sarafloxacin hydrochloride to 30 parts of water for injection, add an appropriate amount of ethanolamine and stir until fully dissolved;

[0036] (3) described propylene glycol, ethanol are mixed and stirred evenly;

[0037] (4) Combine the solution prepared by step (2) and step (3) and stir evenly; adjust the pH to 9.5-11 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts, and then make a compound sarafloxacin hydrochloride Injection.

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PUM

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Abstract

The invention discloses a compound sarafloxacin hydrochloride injection, its preparing process and use thereof, wherein the injection comprises (by weight portions) sarafloxacin hydrochloride 5-20 parts, maize flour 0.25-5 parts, ethanol 50-300 parts, methyl glycol 50-300 parts. The preparing process consists of steps of weighing each constituents, charging water for injection and stirring, adjusting acidity to 9.5-11 with hydrochloric acid or sodium-hydroxide, and charging water for injection to 1000ml.

Description

technical field [0001] The invention relates to a drug injection, a preparation method and use, in particular to a compound sarafloxacin hydrochloride injection, a preparation method and a use. Background technique [0002] Piglet edema disease is an acute and subacute sporadic infectious disease caused by pathogenic Escherichia coli, and the cure rate is low. In recent years, piglet edema disease has been increasing year by year, showing an upward trend. The disease course is short and death is fast. It has become a major obstacle to the development of the pig industry. When one piglet in a litter becomes ill, it will quickly spread to the whole litter. . After the piglets get sick, if comprehensive prevention and control measures are not taken in time, the whole litter of piglets will die; the loss will be great. This disease is extremely harmful to the pig industry. After onset, the preferred drugs are gentamicin, kanamycin and streptomycin sulfate. For a long time, d...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61P1/04A61P31/04A61K31/341
Inventor 魏宗生郭建华耿强斌
Owner TIANJIN SHENGJI GRP CO LTD
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