A local drug-release system and a method of the manufacture thereof

An active ingredient, topical system technology, applied in the directions of non-active ingredient medical preparations, applications, household components, etc., can solve the problem of not being able to manufacture a topical system that releases active ingredients, etc.

Inactive Publication Date: 2007-08-15
HERAEUS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, to date these antibiotics cannot be manufactured by injection molding in topical systems for the release of active ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Vigorously stir 570.0g of polymethyl methacrylate and methyl acrylate copolymer (molecular weight ~ 800,000g / mole), 285.0g of methyl methacrylate, 89.0g of zirconium dioxide, 42.0g of gentamicin sulfate (AK 600), 8.8 g of dibenzoyl peroxide and water mixture with a weight ratio of 3:1 and 15.0 g of glycine were prepared into a paste. Using this viscous paste, approximately spheres with a diameter of 7 mm were formed on a polyfilic surgical wire by injection molding equipment. The spray molding method is carried out at room temperature. Subsequently, the body was hardened in a dryer tunnel at 80°C. The mass of the green body formed was about 240 mg.

Embodiment 2

[0024] Vigorously stir 570.0g of polymethyl methacrylate and methyl acrylate copolymer (molecular weight ~ 800,000g / mole), 285.0g of methyl methacrylate, 89.0g of zirconium dioxide, 45.0g of vancomycin hydrochloride, 8.8g of A 3:1 mixture of dibenzoyl peroxide and water, and 15.0 g of glycine, was made into a paste. Using the resulting paste, an approximate sphere with a diameter of 7 mm was formed on a polyfilic surgical wire by injection molding equipment. Immediately thereafter, the green body is continuously hardened by a heat radiator, and at the same time, the injection molded body is heated to 60-70° C. under the influence of infrared rays, and the polymerization reaction starts. The mass of the cured body was about 240 mg.

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Abstract

A local system for the release of active principle is described which consis ts of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxid e or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerisation, radical polymerisation activators effective in the temperature range of 10-80 .degree.C or residues of these polymerisation activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein. A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylat e or poly-methyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, o ne or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection moulded by an injection moulding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or t he approximately spherical or rotation symmetrical bodies are injection-moulded onto a wire; c) the bodies are heated to a temperature at which the polymerisation initiator decomposes.

Description

technical field [0001] The object of the present invention is a locally effective system for releasing active ingredients, which system is mainly composed of an approximately spherical or rotationally symmetrical body, which is mainly composed of polymethyl methacrylate or polymethyl methacrylate- It is composed of methyl acrylate copolymer, zirconium dioxide or barium sulfate and one or more active ingredients of medicines. Background technique [0002] Even today, a major challenge in orthopedic surgery lies in the treatment of osteomyelitis. Osteomyelitis can be hematogenous, post-traumatic, or post-operative. Particularly difficult to treat is chronic osteomyelitis, which in rare cases can lead to amputation and even sepsis. [0003] The usual approach is surgical salvage with basic surgical debridement. During this procedure, large amounts of infected or dead bone are removed. Subsequently, the bone cavity is filled with a topical antibiotic carrier, or treated by r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/00A61P19/08A61P29/00A61L31/06A61M31/00C08F20/14C08F2/44C08F4/04C08F4/32C08J7/12B29C45/00B29K27/18
CPCA61L2300/406A61K9/1635A61K9/0024A61K9/1611A61L27/16A61J2200/20A61L27/54A61P19/00A61P19/08A61P29/00A61P31/04C08L33/12
Inventor K.-D.·屈恩S.·福格特
Owner HERAEUS MEDICAL
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