A local drug-release system and a method of the manufacture thereof

Abstract

A local system for the release of active principle is described which consis ts of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxid e or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerisation, radical polymerisation activators effective in the temperature range of 10-80 .degree.C or residues of these polymerisation activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein. A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylat e or poly-methyl methacrylate co-methyl acrylate, zirconium dioxide and / or barium sulphate, o ne or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection moulded by an injection moulding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or t he approximately spherical or rotation symmetrical bodies are injection-moulded onto a wire; c) the bodies are heated to a temperature at which the polymerisation initiator decomposes.

Description

technical field [0001] The object of the present invention is a locally effective system for releasing active ingredients, which system is mainly composed of an approximately spherical or rotationally symmetrical body, which is mainly composed of polymethyl methacrylate or polymethyl methacrylate- It is composed of methyl acrylate copolymer, zirconium dioxide or barium sulfate and one or more active ingredients of medicines. Background technique [0002] Even today, a major challenge in orthopedic surgery lies in the treatment of osteomyelitis. Osteomyelitis can be hematogenous, post-traumatic, or post-operative. Particularly difficult to treat is chronic osteomyelitis, which in rare cases can lead to amputation and even sepsis. [0003] The usual approach is surgical salvage with basic surgical debridement. During this procedure, large amounts of infected or dead bone are removed. Subsequently, the bone cavity is filled with a topical antibiotic carrier, or treated by r...

AI Technical Summary

Problems solved by technology

Therefore, to date these antibiotics cannot be manufactured by injection molding in topical systems for the release of active ingredients