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Method of modifying elastin by initiation transition termination agent

An elastin and terminator technology, which is applied in the field of elastin modification by initiating transfer terminators, and can solve problems such as no research reports.

Inactive Publication Date: 2007-08-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no research report on the surface modification of elastin by thio-iniferter technology

Method used

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  • Method of modifying elastin by initiation transition termination agent
  • Method of modifying elastin by initiation transition termination agent
  • Method of modifying elastin by initiation transition termination agent

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] (1) 3 g of unswollen elastin, 1.36 g of triethylamine, and 2.03 g of p-chloromethylbenzoyl chloride were reacted at 20° C. for 15 h, and the product was fully washed and dried to obtain chlorinated elastin.

[0035] (2) 1.5g of chlorinated elastin and 3.84g of sodium diethyldithiocarbamate were reacted at 20°C for 15h, and the product was fully washed and dried to obtain vulcanized elastin, which is a macromolecular thioiniferterminator.

[0036] (3) in N 2 Add 11.2mL of β-hydroxyethyl methacrylate, 11.2mL of anhydrous methanol and 0.50g of macromolecular thio-iniferter under protection, put the reaction bottle into a 250W UV lamp reaction box, and react at 20°C for 15h. The product is fully washed and dried to obtain polymethacrylate-β-hydroxyethyl ester modified elastin polymer.

example 2

[0038] (1) 4 g of unswollen elastin, 20 g of triethylamine, and 57.14 g of p-chloromethylbenzoyl chloride were reacted at 35° C. for 12 h, and the product was fully washed and dried to obtain chlorinated elastin.

[0039] (2) 2.5g of chlorinated elastin and 44.53g of sodium diethyldithiocarbamate were reacted at 25°C for 18h, and the product was fully washed and dried to obtain vulcanized elastin, a macromolecular thioiniferterminator.

[0040] (3) in N 2 Add 50mL of β-hydroxyethyl methacrylate, 60mL of anhydrous methanol and 1.50g of macromolecular thioiniferter under protection, put the reaction bottle into a 300W UV lamp reaction box, and react at 40°C for 48h, and the product passes through Fully washed and dried to obtain polymethacrylate-β-hydroxyethyl ester modified elastin polymer.

example 3

[0042] (1) 5 g of unswollen elastin, 40 g of triethylamine, and 74.75 g of p-chloromethylbenzoyl chloride were reacted at 35° C. for 24 h, and the product was fully washed and dried to obtain chlorinated elastin.

[0043] (2) 4 g of chlorinated elastin and 115.78 g of sodium diethyldithiocarbamate were reacted at 30°C for 24 hours, and the product was fully washed and dried to obtain vulcanized elastin, which is a macromolecular thio-iniferterminator.

[0044] (3) Add 60mL of β-hydroxyethyl methacrylate, 90mL of anhydrous methanol and 3g of macromolecular thio-iniferter under the protection of Ar, put the reaction bottle into a 400W UV lamp reaction box, and react at 35°C After 96 hours, the product was fully washed and dried to obtain an elastin polymer modified by polymethacrylate-β-hydroxyethyl ester.

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Abstract

The invention discloses a modifying method of elastic protein through triggering transmitting terminator, which is characterized by the following: making elastic protein chlorinate through p-chloromethyl benzoyl chloride; sulfurizing diethyl sodium dithiocarbamic acid to make macromolecular triggering transmitting terminator; triggering methyl acroleic acid-beta-hydroxyethyl ester to polymerize irradiated by ultraviolet; synthesizing elastic protein polymer modified by polymethyl acroleic acid-beta-hydroxyethyl ester; modifying the hydrophobicity of elastic protein obviously; reducing heat stability of elastic protein.

Description

technical field [0001] The invention relates to a method for modifying materials by using an iniferter, in particular to a method for modifying elastin by using an iniferter. Background technique [0002] Elastin is an insoluble, highly cross-linked macromolecular fibrous protein in the extracellular matrix. It can combine with microfibrils to form elastic fibers in vivo. Its main function is to passively stretch and endow tissues and organs with elasticity and reversibility. deformation ability. At present, research on elastin at home and abroad is mainly focused on the preparation of tissue engineering scaffolds and biodegradable elastomers using the hydrolyzed products of elastin α-elastin and K-elastin, as well as the synthesis and application of genetically engineered silk-like elastin polymers. , and elastin is difficult to process, produce and shape by chemical and physical methods due to its high insolubility, high hydrophobicity and high cross-linking property, whi...

Claims

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Application Information

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IPC IPC(8): C07K14/435
Inventor 侯信王晓丽吴义春王秀奎
Owner TIANJIN UNIV
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