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Sodium myristyl aldehyde sulfate and its application as immunoadjuvant

A technology of sodium myristoyl acetaldehyde sulfite and immune adjuvant, which is applied in the direction of medical preparations containing active ingredients, anhydride/acid/halide active ingredients, antibody medical ingredients, etc., which can solve the problem of decline, poor antibody production, and inability Cryopreservation and other issues to achieve the effect of good safety, increased activity, and high safety

Inactive Publication Date: 2007-08-22
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of aluminum compounds on improving the antibody production of soluble protein vaccines and purified protein subunit vaccines is poor, and purified subunit vaccines are undoubtedly the future development direction of vaccines; in addition, the adjuvant effect of aluminum compounds will gradually decline after exceeding a certain dose; Other problems are that vaccines containing aluminum compounds cannot be produced by low-temperature freeze-drying technology, nor can they be stored frozen.

Method used

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  • Sodium myristyl aldehyde sulfate and its application as immunoadjuvant
  • Sodium myristyl aldehyde sulfate and its application as immunoadjuvant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, synthesize myristoyl acetaldehyde sodium sulfite according to the following steps:

[0020] ① Synthesis of intermediates

[0021] Add 1.5 kg of slaked lime, add 1.2 kg of water, and stir to form a paste; then add 0.6125 kg of myristic acid and 1.5 kg of acetic acid, mix well, pour into the lime paste, and keep stirring to form 2.5 kg of calcium salt. After dry distillation, 0.5 kg of crude product was obtained; the crude product was distilled under reduced pressure, and constant fractions were collected to obtain 0.377 kg of light yellow intermediate.

[0022] ②, grafting

[0023] 377 grams of intermediates and 20 grams of ethyl formate were dissolved in 2 liters of anhydrous benzene, and poured into a 5-liter round bottom flask. Then 5.76 g of sodium metal was chopped and added to the reaction liquid in portions, shaking from time to time, and keeping the temperature below 40°C. Leave overnight at room temperature. Extracted 4 times with 1500 ml of wa...

Embodiment 2

[0026] Embodiment 2, synthesize myristoyl acetaldehyde sodium sulfite according to the following steps:

[0027] ① Synthesis of intermediates

[0028] Add 1 kg of slaked lime, add 0.8 kg of water, and stir to form a paste; then add 0.5 kg of myristic acid and 1 kg of acetic acid, mix well, pour into the lime paste, and keep stirring to form 1.5 kg of calcium salt. After dry distillation, 0.3 kg of the crude product was obtained; the crude product was distilled under reduced pressure, and constant fractions were collected to obtain 0.25 kg of a light yellow intermediate.

[0029] ②, grafting

[0030] 250 grams of intermediate and 15 grams of ethyl formate were dissolved in 1.5 liters of anhydrous benzene, and poured into a 5-liter round bottom flask. Then chop up 4.6 grams of sodium metal, add to the reaction solution in portions, shake from time to time, and keep the temperature below 40°C. Leave overnight at room temperature. Extracted 3 times with 1000 ml of water, and c...

Embodiment 3

[0033] Embodiment 3, synthesize myristoyl acetaldehyde sodium sulfite according to the following steps:

[0034] ① Synthesis of intermediates

[0035] Add 2 kg of slaked lime, add 1.6 kg of water, and stir to form a paste; then add 0.75 kg of myristic acid and 2 kg of acetic acid, mix well, pour into the lime paste, and keep stirring to form 4 kg of calcium salt. After dry distillation, 0.9 kg of crude product was obtained; the crude product was distilled under reduced pressure, and constant fractions were collected to obtain 0.67 kg of light yellow intermediate.

[0036] ②, grafting

[0037] 670 grams of intermediates and 30 grams of ethyl formate were dissolved in 3 liters of anhydrous benzene, and poured into a 5-liter round bottom flask. Then 7.6 g of sodium metal was chopped and added to the reaction liquid in portions, shaking from time to time, and keeping the temperature below 40°C. Leave overnight at room temperature. Extracted 3 times with 1800 ml of water, and c...

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Abstract

The present invention provides one kind of immunological active matter and immunological adjuvant compound, sodium myristyl aldehyde sulfate. Sodium myristyl aldehyde sulfate has molecular formula of C16H31O5SNa and molecular structure as shown. The present invention proposes the application of sodium myristyl aldehyde sulfate in providing animal with immunological activity and as immunological adjuvant.

Description

Technical field: [0001] The present invention relates to a novel immune active substance and immune adjuvant compound. Background technique: [0002] Houttuyniatin is an active ingredient extracted from Houttuynia cordata, which has various activities such as antibacterial and immune function improvement. Its chemical name is "capryl acetaldehyde". Due to the instability of high-purity caproyl acetaldehyde, it is usually prepared into "caproylacetaldehyde sulfite" with stable properties and unchanged biological activity, and the trade name is "synthetic houttuydine". A series of compounds have been synthesized according to the molecular structure of Houttuynia cordata, and these compounds also have biological activity similar to Houttuynia cordata (see ①, Ye Xiaoli (叶小利), LiXuegang (Li Xuegang). Effect of the Surface Activity on the Antibacterial Activity of Octadecanoyl Acetal SodiumSulfite Series (surface activity and antibacterial activity of octadecanoyl acetaldehyde so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K39/39A61P37/04
Inventor 叶小利李学刚袁吕江
Owner SOUTHWEST UNIV
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