1'-acetoxy chavicol acetic ester

A technology of acetoxypiperol acetate and carbon dioxide, which is applied in the field of preparation of Mycobacterium tuberculosis inhibitors by 1'-acetoxypiperol acetate, can solve problems such as unseen

Inactive Publication Date: 2007-08-22
HONGYI SCI & TECH CO LTD NANCHANG
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also research reports showing that 1'-acetoxypiperol acetate has antitumor properties (Moffatt J, A, et al. [J]. Carcinogenesis, 2000, 21: 2151-2157; zheng Q et al. [J] .J Cancer Res Clin Oncol, 2002, 128:539~546), antibacterial (Janssen A M, [J].planta Med, 1985(6):507~511), antifungal (Ficker C E, etal.[J] .J Ethnophamacal, 2003, 85:589~593), anti-ulcer (Mitsuis, etal.[J].Chem Pham Bull, 1976,24:2377~2382), antioxidant (Kubota K, etal.[J].Spec Publ R Soc Chem, 2001, 274: 601~607), a

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 1'-acetoxy chavicol acetic ester
  • 1'-acetoxy chavicol acetic ester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take the dried rhizome galanga of Zingiberaceae plant Alpinia galanga Willd., dry it to a moisture content of 5.6%, grind it into 18 mesh fine powder, put it in a supercritical carbon dioxide extractor, and the temperature of the extraction kettle is 33°C. The pressure is 15Mpa; the temperature of the separation column is 45°C and the pressure is 10Mpa; the temperature of the desorption kettle is 36°C and the pressure is 8MPa; the instantaneous flow rate of carbon dioxide is 200L / hour; the extraction and separation time is 4 hours. Take the above-mentioned extract separation liquid and pass it through a silica gel chromatography column, elute and refine it with 10:1 n-hexane-ethyl acetate, collect the eluted refined liquid, and dry it under reduced pressure to obtain the compound 1 (1'-acetoxypiperol B esters). The compound (1'-acetoxypiperol acetate) is made into soft capsules, tablets, capsules, pills, granules and injections by conventional preparation methods and us...

Embodiment 2

[0020] Take the dried rhizome galanga of Zingiberaceae plant Alpinia galanga Willd., dry it to a moisture content of 8.2%, grind it into 20 mesh fine powder, put it in a supercritical carbon dioxide extractor, and the temperature of the extraction kettle is 38°C. The pressure is 20Mpa; the temperature of the separation column is 41°C and the pressure is 12Mpa; the temperature of the desorption kettle is 32°C and the pressure is 10MPa; the instantaneous flow rate of carbon dioxide is 250L / hour; the extraction and separation time is 5 hours. Take the above-mentioned extract separation liquid and pass it through a silica gel chromatography column, elute and refine it with 10:1 n-hexane-ethyl acetate, collect the eluted refined liquid, and dry it under reduced pressure to obtain compound 2 (1'-acetoxypiperol B esters). The compound (1'-acetoxypiperol acetate) is made into soft capsules, tablets, capsules, pills, granules and injections by conventional preparation methods and used ...

Embodiment 3

[0022] Take the dried rhizome galanga of Zingiberaceae plant Alpinia galanga Willd., dry it to a moisture content of 7.1%, pulverize it into a 14-mesh fine powder, put it in a supercritical carbon dioxide extractor, and the temperature of the extraction kettle is 40°C. The pressure is 10Mpa; the temperature of the separation column is 50°C and the pressure is 18Mpa; the temperature of the desorption kettle is 45°C and the pressure is 15MPa; the instantaneous flow rate of carbon dioxide is 150L / hour; the extraction and separation time is 6 hours. Take the above-mentioned extract separation liquid and pass it through a silica gel chromatography column, elute and refine it with 10:1 n-hexane-ethyl acetate, collect the eluted refined liquid, and dry it under reduced pressure to obtain compound 3(1'-acetoxypiperolol B esters). The compound (1'-acetoxypiperol acetate) is made into soft capsules, tablets, capsules, pills, granules and injections by conventional preparation methods an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses a supercritical CO2 extraction and silica gel column chromatographic process for extracting, separating and refining 1'-acetoxy chavicol acetic ester with activity of resisting tubercle bacillus infection from dried galangal rhizome as one kind of Zingiberaceae plant.

Description

technical field [0001] The invention relates to a production method of supercritical carbon dioxide extraction and silica gel column chromatography to extract, separate and refine 1'-acetoxy piperonol B from the dry rhizome of Alpinia galanga Willd. Application of esters in the preparation of Mycobacterium tuberculosis inhibitors. Background technique [0002] The English name of 1’-acetoxychavicol acetate is 1’-acetoxychavicol acetate, and its molecular formula is C 13 h 14 o 4 , the molecular weight is 234.25, and the structural formula is On August 10, 2006, Japanese Patent JP2006206541 disclosed a chemical synthesis method of 1'-acetoxypiperol acetate. On July 7, 2005, Japanese Patent JP2005179201 disclosed that 1'-acetoxypiperol acetate isolated from the methanol extract of Galanga galanga fruit can inhibit the replication of HIV-1NL43 in MT-4 cells , but has no effect on the survival of MT-4 cells, showing high safety and the characteristics of inhibiting the ext...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C67/48C07C69/16A61K31/20A61P31/04A61K36/9062
CPCY02P20/54
Inventor 刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap