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Medical combination including rhein or diacetylrhein and the preparing method thereof

A technology of diacetyl rhein and composition, which is applied in the direction of drug combination, antipyretic, pill delivery, etc.

Inactive Publication Date: 2007-09-12
刘德海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

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Method used

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  • Medical combination including rhein or diacetylrhein and the preparing method thereof
  • Medical combination including rhein or diacetylrhein and the preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The preparation of embodiment 1 sodium rhein dispersion and dispersible tablet

[0058] Dissolve 25 grams of sodium rheinate or sodium diacetylrheinate or potassium diacetylrheinate in 4.5 grams of sodium bicarbonate (4.5% aqueous solution) aqueous solution, add 7.5 grams of hydroxyethyl cellulose (as a disintegrant at the same time), Stir well to form solution A; mix and dissolve 2.5 grams of gel, 0.5 grams of spices, 25 grams of sucrose and 60 grams of mannitol to make solution B, mix solution A and solution B, add appropriate amount of water to dilute, and mix well, Put it into the mold to freeze at low temperature, vacuumize it in a freeze dryer, sublimate until the material is completely dry, press seal, and pack. The total weight of the six auxiliary materials is 100 grams, and 1000 tablets are made, each auxiliary material is 100 mg, and the main drug is 25 mg sodium rhein, that is, the weight of the orally disintegrating tablet is 125 mg. After inspection, all ...

Embodiment 2

[0059] The preparation of embodiment 2 melting method solid dispersion and dropping pill

[0060] 1000 grams of composite matrix (PEG-6000: sodium carboxymethyl cellulose = 10: 1) is heated to melt, lower the temperature so that it is between 60 and 70 ° C, and then add 200 grams of rhein or diacetyl rhein powder to the In the PEG-6000 molten liquid, stir rapidly, and after forming molten liquid and / or suspension liquid and / or emulsion liquid, drop it into the condensing agent according to the conventional method to make dropping pills. It can also be crushed after the dispersion is cooled to make other dosage forms.

Embodiment 3

[0061] Example 3 Rhein or sodium rhein or diacetyl rhein or potassium diacetyl rhein 100 grams, add ethanol or aqueous solution, heat to dissolve, put into molten PEG-4000, after fully mixing, vacuum dry, wait to remove After exhausting the solvent, make drop pills according to the conventional method, or cool and pulverize and pack into capsules or make other dosage forms.

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Abstract

The present invention relates to one kind of medicine composition containing rheinic acid or diacetyl rheinic acid and its pharmaceutically acceptable salt, dispersant carrier material and other supplementary material. The medicine composition is prepared through a melting process, a solvent process, a melting-solvent process or a fine grinding process to prepare effective component dispersoid; and further dropping the dispersoid into condensing agent to prepare dripping pill, or other steps to prepare different other preparations. The medicine composition of the present invention has raised bioavailability, and may be applied widely in treating osteoarthritis, rheumatoid arthritis, hyperlipemia and other diseases.

Description

technical field [0001] The present invention relates to a pharmaceutical composition. Specifically, the present invention relates to a solid dispersion pharmaceutical composition composed of rhein or diacetylrhein and a pharmaceutically acceptable salt thereof as an active ingredient, and a dispersion carrier and a preparation method thereof, for the treatment of arthritis, including Osteoarthritis, rheumatism and rheumatoid arthritis, can also be used for cardiovascular diseases, etc. Background technique [0002] Osteoarthritis, rheumatoid arthritis and rheumatoid arthritis are joint diseases with a high incidence rate. Taking the former as an example, the incidence rate is about 10% of the total population. For patients over 60 years old, more than 50% of the patients It affects 2%, 30% and 68% of women under the age of 45, 45 to 60 and over 65, respectively; and 3%, 24.5% and 58% of men. As the population ages, the proportion of the diseased population to the total pop...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/216A61K9/20A61P9/00A61P29/00A61P19/02
Inventor 刘德海
Owner 刘德海
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