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Compound vibramycin injection for animals and the preparing method thereof

A technology of long-acting oxytetracycline and injection, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems such as unstable performance, easy discoloration, and failure, and achieve The effect of long action time, low cost and low chelation temperature

Inactive Publication Date: 2007-10-31
JIANGXI NUCLEAR IND TIANDIHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The performance of domestic oxytetracycline injection is unstable, easy to change color, precipitate and fail

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Take 100ml of water, add 7.5g of magnesium chloride, heat slightly to dissolve, then add 1g of sodium bisulfite to dissolve, then add 51g of oxytetracycline, stir evenly, slowly add about 15ml of ethanolamine to dissolve oxytetracycline , adjust the pH value at 8.0-9.5 with ethanolamine, and set aside. Separately take 200ml of α-pyrrolidone and 150ml of propylene glycol to form a compound organic solvent, heat to 90°C, add 10g of trimethoprim to dissolve, cool to below 60°C, mix with the stock solution, and add water to make up the full amount. Sterile filtration, aseptic subpackaging, ready to use.

Embodiment 2

[0012] Example 2: Take 100ml of water, add 15g of magnesium chloride, heat slightly to dissolve, then add 2g of sodium bisulfite to dissolve, then add 102g of oxytetracycline, stir well, slowly add about 30ml of ethanolamine to dissolve oxytetracycline, Use ethanolamine to adjust the pH value at 8.0-9.5, and set aside. Take another prescription amount of α-pyrrolidone 200ml and propylene glycol 200ml to form a compound organic solvent, heat to 90°C, add 20g of trimethoprim to dissolve, cool to below 60°C, mix with the stock solution, and add water to the full amount. Sterile filtration, aseptic subpackaging, ready to use.

Embodiment 3

[0013] Example 3: Take 100ml of water, add 30g of magnesium oxide, heat slightly to dissolve, then add 4g of sodium bisulfite to dissolve, then add 204g of oxytetracycline, stir evenly, slowly add about 60ml of ethanolamine to dissolve oxytetracycline , adjust the pH value at 8.0-9.5 with ethanolamine, and set aside. Separately take 200ml of α-pyrrolidone and 250ml of propylene glycol to form a compound organic solvent, heat to 90°C, add 40g of trimethoprim to dissolve, cool to below 60°C, mix with the stock solution, and add water to make up the full amount. Sterile filtration, aseptic subpackaging, ready to use.

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PUM

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Abstract

The invention discloses a compound long-acting terramycin injection for animals and preparing method, which is characterized by the following: incorporating 50-300g supercidin, 20-60g trimethoprim or di-trimethoprim, 100-700g composite organic dissolvent, 20-100g magnesium chloride or magnesium oxide, 20-160g aminoethyl alcohol, 1g-10g anti-oxidant and surplus as injecting water. This invention possesses the advantages pf good drug effect, long operational time and low cost.

Description

technical field [0001] The invention relates to a veterinary compound long-acting oxytetracycline injection and a preparation method thereof. Background technique [0002] Oxytetracycline is the most widely used antibiotic for livestock and poultry and other animals. As a basic medicine for livestock and poultry health care, it is usually added to feed or made into injection. Its global drug consumption ranks second over the years. Oxytetracycline is added to feed, which can be used for the prevention and group treatment of various diseases in animals. Oxytetracycline injection is more used for the treatment of indications, and can also be used for animal health care. It is mainly used for respiratory tract, urogenital tract and gastrointestinal tract infections caused by various bacteria, mycoplasma, chlamydia, etc. of animals. It can also be used for three-needle health care for young animals. Unilateral oxytetracycline injection is produced both...

Claims

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Application Information

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IPC IPC(8): A61K31/65A61K9/08A61K47/16A61P31/04A61K31/635
Inventor 王新斌李龙瑞朱斌杨莉
Owner JIANGXI NUCLEAR IND TIANDIHE PHARMA
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