Dried forms of aqueous solubilized bile acid dosage formulation, preparation and uses thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- 柳署弘
- Publication Date
- 2007-10-31
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Background of the invention
[0001] Bile salts, organic acids derived from cholesterol, are natural ionic detergents that play key roles in the absorption, transport and secretion of lipids. The term primary bile acids refers to those synthesized de novo by the liver. In humans, primary bile acids include cholic acid (3α,7α,12α-trihydroxy-5β-cholanic acid) (“CA”) and chenodeoxycholic acid (3α,7α-dihydroxy-5β-cholanic acid) (“CDCA”). Dehydroxylation of these bile acids by gut bacteria produces more hydrophobic secondary bile acids such as deoxycholic acid (3α,12α-dihydroxy-5β-cholanic acid) (“DCA”) and lithocholic acid (3α-hydroxy -5β-cholanic acid) ("LCA"). These four bile acids CA, CDCA, DCA, and LCA generally account for more than 99% of the bile acid pool in the human body. Secondary bile acids that are further metabolized by the liver are sometimes called tertiary bile acids.
[0002] Keto bile acids are produced in the second place in humans as a result of the oxidati...