Dried forms of aqueous solubilized bile acid dosage formulation, preparation and uses thereof

Abstract

The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.

Description

Background of the invention [0001] Bile salts, organic acids derived from cholesterol, are natural ionic detergents that play key roles in the absorption, transport and secretion of lipids. The term primary bile acids refers to those synthesized de novo by the liver. In humans, primary bile acids include cholic acid (3α,7α,12α-trihydroxy-5β-cholanic acid) (“CA”) and chenodeoxycholic acid (3α,7α-dihydroxy-5β-cholanic acid) (“CDCA”). Dehydroxylation of these bile acids by gut bacteria produces more hydrophobic secondary bile acids such as deoxycholic acid (3α,12α-dihydroxy-5β-cholanic acid) (“DCA”) and lithocholic acid (3α-hydroxy -5β-cholanic acid) ("LCA"). These four bile acids CA, CDCA, DCA, and LCA generally account for more than 99% of the bile acid pool in the human body. Secondary bile acids that are further metabolized by the liver are sometimes called tertiary bile acids. [0002] Keto bile acids are produced in the second place in humans as a result of the oxidati...

AI Technical Summary

Problems solved by technology

The few aqueous formulations available are unstable and have very limited use due to pH control and maintenance issues

Also, some commercially available pharmaceutical dosage forms of bile acids have been found to have insufficient bioavailability

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