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Method for preparing acanthopanax senticousus extracting liquid/extraction

A technology of Acanthopanax senticosus and its extract, which is applied in the field of medicine, can solve the problems of reducing the recovery of active ingredients, high toxicity of ethyl acetate, and harm to human body, and achieve the effect of effectively removing impurities, less impurities, and low cost

Active Publication Date: 2007-12-12
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction process will reduce the recovery of active ingredients, and ethyl acetate is highly toxic and flammable, which will cause great harm to the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 Acanthopanax senticosus extract

[0019] Take the Acanthopanax stalk and cut it into 1-3cm pieces. Decoct three times, add 5 times the amount of water for 30 minutes for the first time; add 6 times the amount of water for 40 minutes for the second time; add 10 times the amount of water for 30 minutes for the third time. Combine the decoctions, concentrate to a relative density of 1.10 (measured at 80°C), and when the temperature drops below 40°C, add ethanol to make the alcohol content reach 70%, stir well and let stand for 10 hours, filter, add ethanol to the residue to make the alcohol content reach 70%. When the amount reaches 80%, let it stand for 8 hours, filter, centrifuge the residue, collect the filtrate, recover ethanol until it has no alcohol smell, and obtain a concentrated extract. Add purified water to 15 times the volume of the concentrated extract, and stir evenly. When the temperature drops below 50°C, add 20% fresh lime ...

Embodiment 2

[0020] The preparation of embodiment 2 Acanthopanax senticosus extract

[0021] Take the Acanthopanax stalk and cut it into 1-3cm pieces. Boil twice, add 4 times the amount of water for the first time and cook for 40 minutes; add 8 times the amount of water for the second time and cook for 60 minutes. Combine the decoctions, concentrate to a relative density of 1.08 (measured at 80°C), and when the temperature drops below 40°C, add ethanol to make the alcohol content reach 75%, stir evenly and let stand for 18 hours, filter, add ethanol to the residue to make the alcohol content reach 75%. When the content reaches 85%, let it stand for 12 hours, filter, centrifuge the residue, collect the filtrate, recover ethanol until it has no alcohol smell, and obtain a concentrated extract. Add purified water to 18 times the volume of the concentrated extract, and stir evenly. When the temperature drops below 50°C, add 10% fresh lime milk to adjust the pH value to 12.00. After stirring e...

Embodiment 3

[0022] The preparation of embodiment 3 Acanthopanax senticosus extract

[0023] Take the Acanthopanax stalk and cut it into 1-3cm pieces. Boil 3 times, add 5 times the amount of water for 30 minutes for the first time; add 6 times the amount of water for 40 minutes for the second time; add 4 times the amount of water for 50 minutes for the third time. Combine the decoctions, concentrate to a relative density of 1.17 (measured at 80°C), and when the temperature drops below 40°C, add ethanol to make the alcohol content reach 65%, stir evenly and let stand for 6 hours, filter, add ethanol to the residue to make the alcohol content reach 65%. When the content reaches 75%, let it stand for 4 hours, filter, centrifuge the residue, collect the filtrate, recover ethanol until it has no alcohol smell, and obtain a concentrated extract. Add purified water to 15 times the volume of the concentrated extract, and stir evenly. When the temperature drops below 50°C, add 30% fresh lime milk ...

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PUM

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Abstract

The invention discloses a process for preparing acanthopanax root extract / substance, which comprises steps of: (1) preparing acanthopanax root medicinal extract by employing water extraction and ethanol deposition method, (2) diluting the extract with right amount of water, adjusting the pH to 10.00-12.00 with lime cream, stirring homogeneously and adjusting the pH to 4.5-6.5 with sulfuric acid, stewing, extracting the supernatant fluid and filtering, concentrating, alcohol depositing, (3) freezing, stewing and removing impurities, obtaining acanthopanax root extract, or carrying out concentrating, decompressing and drying to obtain acanthopanax root extract.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method of Acanthopanax japonicus extract. Background technique [0002] Acanthopanacis (Radix Acanthopanacis Senticosi) is a deciduous shrub of Araliaceae, 1-6m high. Branches often densely grow needle-like downward thin spines. Palmately compound leaves with 5 leaflets, elliptic obovate or oblong, with heavily serrated margins. Umbels single terminal or 2-6 clustered, petals yellowish white or purple. Fruit spherical, black when ripe. Distributed in Northeast China, Hebei, and Shanxi, it grows in coniferous and broadleaf mixed forests at altitudes below 800m (Northeast) to 1500-2000m (North China). It is also distributed in the Korean Peninsula, the former Soviet Union, and Japan. The medicinal value is similar to that of ginseng. The endangered species under national third-level protection. [0003] Acanthopanax injection is a sterilized injection obtained by extrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P9/10A61P7/02A61K125/00
Inventor 方同华
Owner HARBIN ZHENBAO PHARMA
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