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Method for preparing paeonol and paeoniflorin from cortex moutan

A technology for paeonol and paeoniflorin is applied in the field of preparing paeonol and paeoniflorin step by step, which can solve the problems of limited application, waste of raw materials and the like, and achieve the effects of improving purity, low cost and reasonable design.

Inactive Publication Date: 2007-12-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are not many patents and literature reports on extracting paeonol from paeonol. In order to increase the yield, more cumbersome methods such as supercritical are often used, which require a certain scale of equipment and equipment, which limits the application in industrial production.
And there is currently no method to obtain paeonol and paeoniflorin from paeonol at the same time, which causes waste of raw materials to a certain extent. Therefore, it is particularly important to establish a method that can simultaneously obtain these two main substances from medicinal materials. important

Method used

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  • Method for preparing paeonol and paeoniflorin from cortex moutan

Examples

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Embodiment 1

[0026] Take 500kg of paeonol decoction pieces, dry at 50°C for 6 hours, soak in water for 24 hours, reflux extraction, collect the distillate to 12 times the amount (6L), freeze at -4°C for 8 hours, take out and thaw and filter immediately, the insoluble matter is Dan skin phenol. Add 10 times the amount of 70% ethanol aqueous solution to the dregs, heat and reflux extraction twice in a slightly boiling state, each time for 0.5 hours, filter the extract, combine, concentrate under reduced pressure to 1g / mL (crude drug amount), and go to D 201 Macroporous resin (0.2-0.6g raw medicinal material / g wet resin). Rinse with 4BV of deionized water, discard, continue to purify with 4BV of 20% ethanol aqueous solution, discard, and then elute with 4BV of 40% ethanol aqueous solution, collect the eluate, concentrate under reduced pressure to no alcohol, and freeze-dry to obtain Paeoniae Alba glycoside part. According to liquid phase determination, the extraction rate of paeonol is 2.06...

Embodiment 2

[0028] Take 500kg of paeonol decoction pieces, dry at 50°C for 6 hours, soak in water for 10 hours, reflux extraction, collect the distillate to 8 times the amount (4L), freeze at -4°C for 4 hours, take out and thaw and filter immediately, the insoluble matter is Dan skin phenol. Add 10 times the amount of 30% ethanol aqueous solution to the dregs, heat and reflux once in a slightly boiling state, and extract once for 0.5 hours each time. The extracts are filtered, combined, concentrated under reduced pressure to 1g / mL (crude drug amount), and listed in D 201 Macroporous resin (0.2-0.6g raw medicinal material / g wet resin). Rinse with 2BV of deionized water, discard, continue to purify with 3BV of 10% ethanol aqueous solution, discard, and then elute with 3BV of 30% ethanol aqueous solution, collect the eluate, concentrate under reduced pressure to no alcohol, and freeze-dry to obtain Paeoniae Alba glycoside part. According to liquid phase determination, the extraction rate o...

Embodiment 3

[0030] Take 500kg of paeonol decoction pieces, dry at 50°C for 6 hours, soak in water for 15 hours, reflux extraction, collect the distillate to 12 times the amount (6L), freeze at -4°C for 6 hours, take out and thaw and filter immediately, the insoluble matter is Dan skin phenol. Add 8 times the amount of 50% ethanol aqueous solution to the dregs, heat and reflux in a slightly boiling state to extract twice, each time for 0.5 hours, filter the extract, combine, concentrate under reduced pressure to 1g / mL (crude drug amount), and apply to D 201 Macroporous resin (0.2-0.6g raw medicinal material / g wet resin). Rinse with 3BV of deionized water, discard, continue to purify with 3BV of 20% ethanol aqueous solution, discard, and then elute with 3BV of 50% ethanol aqueous solution, collect the eluate, concentrate under reduced pressure to no alcohol, and freeze-dry to obtain Paeoniae Alba glycoside part. According to liquid phase determination, the extraction rate of paeonol is 1....

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Abstract

The invention relates to a method for preparing paeonol and peony glycosides from root bark of tree peony. It compries following steps: immersing pieces of medical herb of root bark of tree peony in water, extracting through distillation and getting paeonol crystal; extracting dregs of a decoction with alcohol solution, decompressing extract, separating extract with D201 macroporous absorption resin and getting peony glycosides. The invention is characterized by full use of medical herb, increased peony glycosides purity, rational design, low cost, easy operation, good stability and suitability for industrial production.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method for obtaining paeonol and paeoniflorin step by step through extraction and refining of traditional Chinese medicine paeonol. Background technique [0002] At present, Chinese herbal medicine has a certain market all over the world. With the increase of people's awareness of health requirements and the aging of the population, sub-health status, people are more eager to return to nature, and use pure natural medicine with high degree of treatment, To prevent problems that cannot be solved by some chemically synthesized drugs, the application of natural herbal medicines is beyond the background of its original national traditional culture. It has become the goal pursued by pharmaceutical companies all over the world to seek medicines with low side effects and high quality and low price from natural medicines. The European Community has carried out unified l...

Claims

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Application Information

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IPC IPC(8): C07C49/255C07H17/04A61K36/71A61K125/00
Inventor 贺庆葛志伟程翼宇水文波窦静
Owner ZHEJIANG UNIV
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