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Hydrolyzed-silk-containing composition for oral cavity

A composition and oral technology, which are applied in the directions of oral care, cosmetic preparations, medical science, etc., to achieve the effects of improving preventive effect, improving collagen decomposition inhibitory effect, and improving demineralization inhibitory effect

Active Publication Date: 2010-12-15
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In this way, all the known technologies exist in the adsorption and protection effects on the dentin of the teeth treated in a short time, the tooth surface retention of active ingredients such as fluorine and antibacterial agents, the stability in the preparation, and the fragrance of the composition. big subject

Method used

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  • Hydrolyzed-silk-containing composition for oral cavity
  • Hydrolyzed-silk-containing composition for oral cavity
  • Hydrolyzed-silk-containing composition for oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～7

[0047] A model toothpaste was formulated according to the recipe in Table 1 below. As the hydrolyzed silk obtained by the phosphoric acid hydrolysis method, silk BN-P manufactured by NDC Co., Ltd. with a number average molecular weight of 500 was used. As the hydrolyzed silk obtained by other than the phosphoric acid hydrolysis method, silk peptide M-500 (manufactured by Cosmo Foods Co., Ltd., number average molecular weight 500), Promois (registered trademark) silk 1000p (manufactured by Chengwa Kasei Co., Ltd., number average molecular weight 1000) were used. ), silk peptide 5 (manufactured by Kanebo Co., Ltd., number average molecular weight 1500), silk powder FD (manufactured by Kanebo Co., Ltd., number average molecular weight 5000). In addition, the 7% silk fibroin aqueous solution uses the product prepared with reference to the reference example 1 (preparation method of the silk fibroin aqueous solution) of the Japanese Patent Application Publication No. 2001-226242. T...

Embodiment 8～19

[0051] Prepare phase A in which water-soluble ingredients (hydrolyzed silk, sodium fluoride, sodium monofluorophosphate, sodium saccharin, xylitol, 70% sorbitol, etc.) are mixed and dissolved in purified water at room temperature. Here, the hydrolyzed silk was similar to the above (1), and as the hydrolyzed silk obtained by the phosphoric acid hydrolysis method, silk BN-P manufactured by NDC Co., Ltd. with a number average molecular weight of 500 was used. As the hydrolyzed silk obtained by other than the phosphoric acid hydrolysis method, silk peptide M-500 (manufactured by Cosmo Food Co., Ltd., number average molecular weight 500), Promois (registered trademark) silk 1000p (manufactured by Seiwa Kasei Co., Ltd., number average molecular weight 1000) were used. ), silk peptide 5 (manufactured by Kanebo Co., Ltd., number average molecular weight 1500), silk powder FD (manufactured by Kanebo Co., Ltd., number average molecular weight 5000). In addition, because the permitted co...

Embodiment 20

[0052] (3) preparation of mouthwash (embodiment 20,21)

[0053] Pour a specified amount of purified water into a stainless steel container equipped with a mixer equipped with a Sany motor and a stirring paddle, and add water-soluble ingredients such as hydrolyzed silk among the compounding ingredients while stirring, and dissolve them. On the other hand, a predetermined amount of organic solvent such as ethanol was added to another stainless steel container equipped with a stirrer having a Sany motor and a stirring blade, and the oil-soluble components among the compounding components were added and dissolved while stirring. Furthermore, the said oil-soluble component was added to the container in which the water-soluble component was melt|dissolved, and it stirred for 1 minute - 30 minutes, and it was made into a uniform solution, and the mouthwash liquid was obtained.

[0054] (4) Dentin collagen decomposition inhibition test

[0055]The bovine dentin collagen decomposition...

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Abstract

A composition for the oral cavity characterized by containing: a hydrolyzed silk having a number-average molecular weight, as calculated from total nitrogen amount and the amount of amino-form nitrogen, of 200-6,000; and a fluorine compound.

Description

technical field [0001] The present invention relates to a composition for oral cavity that effectively protects teeth by covering them with hydrolyzed filaments having high adsorption properties to dentin of teeth to block bacteria, acids, enzymes, etc. Retention, significantly prevent the dissolution and decomposition of dentin, thereby dramatically improving the caries prevention effect of dentin. Background technique [0002] Conventionally, methods such as toothpaste, mouthwash, gel, tablet, gum (gummy), and chewing gum have been used as methods for causing active ingredients to act on teeth. However, there are problems in that the amount of the active ingredient in the oral cavity is insufficient after the toothpaste or mouthwash is spit out, the usability of the cream and the gel is poor, and the embedding of the solid causes pain. In addition, in all cases, there is a problem that the concentration of the active ingredient decreases and the effect decreases due to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/21A61Q11/00
CPCA61K8/64A61K8/21A61Q11/00
Inventor 福田康齐藤浩一
Owner LION CORP