Azithromycin orally disintegrating tablets and method for preparing the same

A technology of orally disintegrating tablets and azithromycin, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as the preparation method of azithromycin orally disintegrating tablets, and achieve improvement Medication compliance, high bioavailability, and the effect of overcoming drug resistance

Inactive Publication Date: 2008-01-30
上海爱的发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, although azithromycin raw materials and tablets, capsules, suspensions, and aqueous injections have been produced in my country and used clinically, there are no reports of azithromycin orally disintegrating tablets and its preparation methods at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Azithromycin 600g

[0037] Acrylic resin E100 110g

[0038] Acrylic resin NE30D (dispersion containing 30% NE) 183.3g

[0039] Silica 33g

[0040] Mannitol 1200g

[0041] Cross-linked polyvinylpyrrolidone 250g

[0042] Aspartame 50g

[0043] Banana flavor 20g

[0044] Magnesium Stearate 40g

[0045] Dissolve acrylic resin E100 in ethanol, add sieved acrylic resin NE30D solid dispersion, stir until completely dissolved; then add silicon dioxide, continue stirring for 1 to 2 hours; put the sieved azithromycin raw material and silicon dioxide into In the bottom spray fluidized bed coating machine, heat under the air flow and spray the coating suspension on the raw material, the inlet air temperature: 50°C, the material temperature: 28°C, the spray pressure: 0.15Mpa, the liquid spray rate: 6g After the coating process is completed, dry for 2 hours; pass mannitol, cross-linked polyvinylpyrrolidone, aspartame and banana essence through a 0.5mm sieve, pour into a three-...

Embodiment 2

[0047] Azithromycin 600g

[0048] Acrylic resin E100 150g

[0049] Acrylic resin NE30D (dispersion containing 30% NE) 250g

[0050] Silica 80g

[0051] Mannitol 1500g

[0052] Cross-linked polyvinylpyrrolidone 280g

[0053] Aspartame 60g

[0054] Banana flavor 25g

[0055] Magnesium Stearate 50g

[0056] Dissolve acrylic resin E100 in ethanol, add sieved acrylic resin NE30D solid dispersion, stir until completely dissolved; then add silicon dioxide, continue stirring for 1 to 2 hours; put the sieved azithromycin raw material and silicon dioxide into In the bottom spray fluidized bed coating machine, heat under the air flow and spray the coating suspension on the raw material, the inlet air temperature: 56°C, the material temperature: 29°C, the spray pressure: 0.18Mpa, the liquid spray rate: 8g After the coating process is completed, dry for 2 hours; pass mannitol, cross-linked polyvinylpyrrolidone, aspartame and banana essence through a 0.5mm sieve, pour into a three-ph...

Embodiment 3

[0058] Azithromycin 600g

[0059] Acrylic resin E100 180g

[0060]Acrylic resin NE30D (dispersion containing 30% NE) 300g

[0061] Silica 96g

[0062] Mannitol 1675g

[0063] Cross-linked polyvinylpyrrolidone 312g

[0064] Aspartame 80g

[0065] Banana flavor 35g

[0066] Magnesium Stearate 65g

[0067] Dissolve acrylic resin E100 in ethanol, add sieved acrylic resin NE30D solid dispersion, stir until completely dissolved; then add silicon dioxide, continue stirring for 1 to 2 hours; put the sieved azithromycin raw material and silicon dioxide into In the bottom spray fluidized bed coating machine, heat under the air flow and spray the coating suspension on the raw material, the inlet air temperature: 65°C, the material temperature: 30°C, the spray pressure: 0.20Mpa, the liquid spray rate: 10g / minute, after the coating process is completed, dry for 2 hours; pass mannitol, cross-linked polyvinylpyrrolidone, aspartame and banana essence through a 0.5mm sieve, pour into ...

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PUM

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Abstract

The present invention discloses an azithromycin orally disintegrating tablet and preparation method. The azithromycin orally disintegrating tablet of the present invention is composed of main medicine, excipients and coating materials, the preparation method adopts the modern preparation technology, the quality of the product is stable, and the invention can provide the azithromycin orally disintegrating tablet which is safe, effective, fast in absorption and high in bioavailability to broad patients.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an orally disintegrating azithromycin tablet prepared by modern tablet technology and a preparation method thereof. Background technique [0002] Azithromycin (azithromycin) is a 15-membered ring macrolide antibiotic developed by SOOR PLIVA company in Croatia at the end of the 20th century. Because of its broad-spectrum antibacterial activity, acid stability, long-acting and high bioavailability, it was quickly promoted worldwide. [0003] According to literature reports, azithromycin is not only used for the treatment of acute pharyngitis, tonsillitis, acute otitis media, acute sinusitis, acute bronchitis, chronic bronchial exacerbation, atypical pneumonia, and bacterial pneumonia, but also for genitourinary system inflammation. [0004] At present, although azithromycin raw materials and tablets, capsules, suspensions, and aqueous injections have been pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7052A61K9/20A61K47/32A61P31/04
Inventor 胡愈璋陈敏娟徐景
Owner 上海爱的发制药有限公司
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