Medicine composition for treating osteoporosis or preventing bone fracture caused by osteoporosis and its application

A technology for osteoporosis and osteoporosis, which is applied in the field of pharmaceutical compositions containing alendronic acid or its salts, parathyroid hormone or its derivatives, and can solve the problem of inability to cure osteoporosis and bone formation. It has the effect of promoting osteoblast formation and bone mineralization, promoting bone formation, and promoting bone formation.

Inactive Publication Date: 2008-02-20
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these drugs inhibit bone resorption, but have a poor effect on bone formation, so these drugs can only prevent and stabilize osteoporosis but cannot cure it

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The present invention will be further described below in conjunction with the examples, but the present invention is not limited thereto. Each main component is calculated by active content in the embodiment:

[0020] active ingredient

Example 1

Example 2

Example 3

Example 4

Example 5

alendronate

parathyroid hormone

Vitamin D

calcium salt

10mg

70μg

6μg

600mg

70mg

10μg

35mg

30μg

2.5μg

1200mg

10mg

100μg

5mg

150μg

10μg

900mg

[0021] Carried out following test to this pharmaceutical composition:

[0022] 800 postmenopausal women with vertebral fractures were treated with this medicinal composition every day and were randomly compared with placebo. It was found that the pharmaceutical composition is better tolerated than the placebo, the risk of spinal fractures is reduced by 2 / 3, the risk of non-spine fractures is...

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PUM

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Abstract

The present invention provides a pharmaceutical composition containing alendronate or the pharmaceutical acceptable salt thereof and parathyroid hormone or the derivatives thereof, the pharmaceutical composition can also be added with vitamin D and calcium salt. The pharmaceutical composition of the present invention can be used for the treatment of osteoporosis, on the one hand, the present invention can inhibit the bone resorption fundamentally, on the other hand, the present invention can increase the bone mass and improve the bone formation, the two-pronged approach can ensure the patients to get the scientific and comprehensive treatment, so as to achieve the purposes of treatment of osteoporosis, the prevention of occurrence of bone fracture and the treatment of the fractures caused by osteoporosis.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating osteoporosis or preventing fractures caused by osteoporosis, in particular to a pharmaceutical composition containing alendronic acid or its salt, parathyroid hormone (PTH) or its derivatives The pharmaceutical composition belongs to the technical field of medicine. Background technique [0002] Osteoporosis is a systemic disease that occurs during the aging process and is characterized by decreased bone mass and destruction of bone microstructure, bone thinning, and decreased number of trabecular bone, resulting in increased bone fragility and prone to fractures. Sexual bone metabolism disorders. When the above phenomena are present and the patient is accompanied by certain clinical symptoms caused by osteoporosis, it is called osteoporosis. Specifically, osteoporosis is a disease characterized by a decrease in the proportion of bone mineral components and bone matrix per unit volume...

Claims

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Application Information

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IPC IPC(8): A61K38/29A61K9/10A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61P19/10A61K31/663A61K31/59
Inventor 郭卫芹张育李国聪
Owner CSPC OUYI PHARM CO LTD
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