Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound aminophenazone barbital Injection and method of producing the same

A technology of compound ammonium barbiturate and its production method, which is applied in the field of compound ammonium barbiturate injection, can solve the problems of accelerated oxidative discoloration, yellowing of color and luster, easy oxidative discoloration, etc., achieve stable quality, and avoid the occurrence of injections. Yellow, stable and reliable product quality

Inactive Publication Date: 2008-02-27
TIANJIN PHARMA GROUP XINZHENG
View PDF0 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Compound ammonium barbiturate injection is an antipyretic and analgesic drug widely used clinically, especially in the rural pharmaceutical market in my country, where it is more widely used clinically; Especially when exposed to light, heat, and heavy metal ions, its oxidative discoloration is accelerated, and its appearance is characterized by yellowing of color.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1, compound aminopyrine barbiturate injection, be 5.0% aminopyrine, 2.0% antipyrine, 0.9% barbiturate, 0.0014% ethylene glycol by weight volume ratio (mg / ml) Composed of disodium amine tetraacetate and water for injection.

[0013] The production method of the above-mentioned injection comprises the steps of adding the main drug aminopyrine, antipyrine and barbiturate to the water for injection, mixing and encapsulating, filling the water with CO 2 To saturation, the temperature of water for injection is 60°C; add complexing agent disodium ethylenediamine tetraacetate to the water for injection before adding the main ingredient; 2 30 minutes; filled with inert gas N after potting 2 . Add activated carbon with a weight volume ratio of 0.05% to the potting waste products and light inspection waste products, stir and absorb for 15 minutes, add the same batch of liquid medicine and refilter to pass the potting.

Embodiment 2

[0014] Embodiment 2, in the present embodiment, compound aminopyrine barbiturate injection is made of aminopyrine of 5.15% by weight volume ratio, 2.1% of antipyrine, 0.95% of barbiturate, 0.0016% of ethylenediamine tetramine Composed of disodium acetate and water for injection. In its production method, the temperature of water for injection is 65°C; after it is prepared to the full amount and fully stirred, continue to fill with CO 2 40 minutes; add activated carbon with a weight volume ratio of 0.05% to the potting waste products and light inspection waste products, and stir and adsorb for 25 minutes. Others are the same as embodiment 1.

Embodiment 3

[0015] Embodiment 3, in the present embodiment, compound aminopyrine barbiturate injection is made of aminopyrine of 5.3% by weight volume ratio, 2.2% of antipyrine, 1.0% of barbiturate, 0.0018% of ethylenediamine tetramine Composed of disodium acetate and water for injection. In its production method, the temperature of the water for injection is 70°C; after making up to the full amount and fully stirring, continue to fill with CO 2 50 minutes; add activated carbon with a weight volume ratio of 0.05% to the potting waste products and lamp inspection waste products, and stir and adsorb for 35 minutes. Others are the same as embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a compound aminolinbarbitone injection and manufacturing method, which comprises the following parts: 5. 0-5. 3% aminobilin, 2. 0-2. 2% analgesine, 0. 9-1. 0% barbitone, 0. 0014 -0. 0018% disodium calcium ethylene diamine and injecting water. The manufacturing method of compound aminolinbarbitone injection comprises the following steps: injecting 5. 0-5. 3% aminobilin, 2. 0-2. 2% analgesine and 0. 9-1. 0% barbitone into injecting water; blending; embedding; aerating CO2 into the injecting water until saturating; setting the temperature of the injecting water at 60-70 deg. c; adding complex builder into the injecting water before adding the main drug components; dispensing to stir evenly; aerating CO2 continuously over 30 min; embedding to aerate N2. The invention is added with 0. 05% active char to stir to adsorb over 15 min to add the same batch of drug liquid to refilter and embed, which stabilizes the injection quality.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, in particular to a compound ammonium barbital injection and a production method thereof. Background technique [0002] Compound Amidopyrmi-Barbiturate Injection (Latin name: Injectio AmidopyrmiComposita) is a compound pharmaceutical preparation containing 50 mg of aminopyridine, 20 mg of antipyridine and 9 mg of barbiturate per milliliter, and is an antipyretic and analgesic drug. Among them, aminopyrine and antipyrine belong to pyrazolone antipyretic and analgesic drugs, which can inhibit the synthesis and release of hypothalamic prostaglandins, restore the normal reactivity of sensory neurons in the temperature regulation center and play an antipyretic effect; It also acts as an analgesic by inhibiting the synthesis of prostaglandins and the like. Aminopyrine can also inhibit the synthesis and release of prostaglandins in local tissues of inflammation, stabilize the lysosome membr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/4152A61K31/515A61P29/00
Inventor 陈智锋
Owner TIANJIN PHARMA GROUP XINZHENG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com