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Fumed silica for use as auxiliary in pharmaceutical and cosmetic compositions

A technology of pyrolytic silica and cosmetic composition, which is applied in the direction of silica, silicon oxide, silicon compounds, etc., and can solve the problem that auxiliary substances have no pharmacological effects

Inactive Publication Date: 2008-02-27
DEGUSSA AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, auxiliary substances have no pharmacological effect

Method used

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  • Fumed silica for use as auxiliary in pharmaceutical and cosmetic compositions
  • Fumed silica for use as auxiliary in pharmaceutical and cosmetic compositions
  • Fumed silica for use as auxiliary in pharmaceutical and cosmetic compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0185] Example 1: The BET surface area is about 200m 2 / g fumed silica

[0186] 70 kg / h of silicon tetrachloride and 35 kg / h of methyltrichlorosilane were evaporated and transferred by means of nitrogen into the mixing chamber of the burner. At the same time, introduce 40Nm into the mixing chamber 3 / h of hydrogen and 195Nm 3 / h of primary air. The mixture exhibited a temperature of 90°C. It is ignited and the flame burns into the reaction chamber. In addition, introduce 30Nm into the reaction chamber 3 / h of secondary air surrounding the flame.

[0187] The reaction gas and the silica formed are sucked out through the cooling system by applying a partial vacuum, cooling its temperature to between 100 and 160°C. The solids are separated from the waste stream in filters or cyclones and then steamed at a temperature of 450°C.

[0188] Sum of reaction enthalpy from partial reactions: -196.1KW; heat capacity of product: 0.13KJ / s·K; adiabatic flame temperature: 1572°C. ...

Embodiment 2

[0190] Example 2: BET surface area is about 300m 2 / g fumed silica

[0191] 160 kg / h of silicon tetrachloride and 20 kg / h of methyltrichlorosilane were evaporated and transferred by means of nitrogen into the mixing chamber of the burner. At the same time, introduce 58Nm into the mixing chamber 3 / h of hydrogen and 190Nm 3 / h of primary air. The mixture exhibited a temperature of 90°C. It is ignited and a flame is allowed to burn into the reaction chamber. The discharge velocity from the burner was 33.6 m / s. In addition, introduce 60Nm into the reaction chamber 3 / h of secondary air surrounding the flame. The ratio of secondary air to primary air is 0.28.

[0192] The reaction gas and the silica formed are sucked out through the cooling system by applying a partial vacuum, cooling its temperature to between 100 and 160°C. The solids are separated from the exhaust gas in a filter or cyclone, followed by steaming at a temperature of 560 °C.

[0193] Sum of reaction...

Embodiment 3

[0195] Example 3: Densified Fumed Silica

[0196] The fumed silica of Example 1 was densified according to the procedure given in US 4877595 . The tapped density is 120 g / l (according to DIN 55943).

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Abstract

Fumed silica for use as auxiliary substance in pharmaceutical and cosmetic compositions, which has - a BET surface area of 90 to 400 m<2> / g - a content of As, Cd, Cr, Pb, Sb and Se of less than 1 ppm for each element and less than 5 ppm of Hg, all elements determined by Inductively Coupled Plasma - Atomic Emission Spectroscopy (ICP-AES) or Atomic Absorption Spectroscopy (AAS).

Description

technical field [0001] The present invention provides high-purity fumed silica for use as an auxiliary agent in pharmaceutical and cosmetic compositions. Background technique [0002] Medicines usually contain two groups of substances with different functions, namely the active ingredient and auxiliary substances (excipients). [0003] The active ingredients are characterized by their specific pharmacological action. They represent active ingredients of medicines. Therefore, they are quantitatively indicated on packaging and packaging inserts. [0004] Auxiliary substances, on the other hand, have no pharmacological effect. They are required to be suitable for the preparation of suitable administration forms for the active ingredients, ie medicaments. Medicines usually contain several auxiliary substances with different functions. For example, auxiliary substances serve as fillers, binders, disintegrants, lubricants or release agents. [0005] A large number of auxilia...

Claims

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Application Information

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IPC IPC(8): C01B33/18A61K47/04A61K8/25
CPCC01P2006/12C09C1/3036C09C1/3081C09C1/30C01P2004/62C01P2006/11C01B33/183C01P2006/80Y02P20/129
Inventor 请求不公布姓名
Owner DEGUSSA AG
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