Calcium sulphate bead string implantation type medicine partial releasing system with top coat and method of producing the same

A technology of calcium sulfate beads and surface coating, which is applied in the field of biomedicine and can solve problems such as unstable drug release speed, sudden release, and slow degradation speed

Inactive Publication Date: 2008-03-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcium phosphate is used as the carrier, and its degradation rate is slow. Although calcium sulfate is used as the carrie

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0027] Example 1 Calcium sulfate / cephalexin / gut polyglycolide system

[0028] Take 2g of calcium sulfate, add 0.02g of cephalexin and mix well, then add 0.5ml of distilled water, and stir well, when the calcium sulfate is initially set, inject it into the beaded mold, the mold is placed in advance with a diameter of 0.1mm and a length of 10cm The gut thread; the mold is vacuum dried at 40°C, the calcium sulfate is fully coagulated, and then the mold is released to obtain drug-loaded calcium sulfate beads.

[0029] Take 0.1g polylactic acid, dissolve it in 7.0ml chloroform (10.0g), place the beads in a rotating chamber, spray the pre-prepared polylactic acid solution evenly on the surface of the beads, and place them in a vacuum drying oven to dry. The calcium sulfate bead release material coated with PLA is prepared. The polymer in the surface coating material can be replaced with polyhydroxybutyrate and its copolymers.

example 2

[0030] Example 2 Calcium sulfate / antibiotic / collagen thread / chitosan system

[0031] Take 6.0g of calcium sulfate, add 0.3g of gentamycin sulfate, then add 1.8ml of distilled water, stir well, when the calcium sulfate is initially set, inject the mixture into a mold made of silicone rubber (the diameter is 0.4mm, the length is 30cm The collagen thread is placed in the mold), the calcium sulfate is fully condensed and then the mold is released, and dried in vacuum at 60°C to obtain drug-loaded calcium sulfate beads. Natural biodegradable polymer, synthetic degradable polymer

[0032] Take 0.5g of chitosan and dissolve it in 10.0ml of 1M acetic acid solution (10.0g), place the beads in the rotating chamber, spray the pre-prepared chitosan solution evenly on the surface of the beads, and place them on the surface of the beads. It is dried in a vacuum drying box to prepare a calcium sulfate bead release material coated with chitosan. The polymer in the surface coating material can be ...

example 4

[0036] Example 4 Calcium Sulfate / Adriamycin / Collagen Thread / Carrageenan-Sodium Alginate System

[0037] Take 4.0g of calcium sulfate, add 0.08g of doxorubicin and mix well, then add 2.8ml of distilled water, and stir well, when the calcium sulfate is initially set, inject it into the mold (the diameter is 0.3mm, the length is 20cm The collagen thread is placed in the mold in advance), the calcium sulfate is fully condensed and then the mold is released, and dried in vacuum at 40° C. to obtain drug-loaded calcium sulfate beads.

[0038] Take 0.1g carrageenan and 0.1g sodium alginate, dissolve them in 10ml distilled water (10.0g), place the beads in the rotating chamber, spray the pre-prepared polymer glue solution evenly on the surface of the beads, and place them It is dried in a vacuum drying oven to prepare a calcium sulfate bead release material coated with carrageenan. Anticancer drugs can be replaced with camptothecin or paclitaxel.

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Abstract

The present invention relates to a calcium sulfate beaded implanted type locally-released medicine system and its preparation method. Said system is composed of three portions of medicine-carried bead bodies, stringing thread and bead body surface coating material, in which the bead bodies are formed from calcium sulfate and medicine according to the weight mixing ratio of 100:1-5. Besides, said invention also provides the concrete operation steps of its preparation method.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to a calcium sulfate bead implantation type local drug release system with a surface coating and a preparation method. Background technique [0002] The local drug release system has the characteristics of low toxicity and long drug effect. At present, most of the implant carrier materials at home and abroad are mainly polymers, such as polylactic acid and its copolymers, polyvinyl lactone, polyvinyl alcohol and various natural macromolecules. Bio-inorganic materials such as calcium phosphate can also be used for loaded drugs There are anti-cancer drugs, antibiotics and protein drugs. For example, polyanhydride-loaded carbazide implant materials have passed FDA review in the United States for the treatment of glioma. Anticancer drugs loaded with inorganic materials can be used as filling materials after bone cancer surgery, and have dual functions of bone repair and local ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/04A61M31/00
Inventor 刘宇高建平马志清李敏
Owner TIANJIN UNIV
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