Application of white fleece-flower root or white fleece-flower root diketone A in the preparation of medicament for treating neurological disorders

A kind of neurodegenerative disease, Baishouwudione technology, applied in the field of medicine

Inactive Publication Date: 2008-03-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, no drug or therapy has achieved satisfactory results

Method used

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  • Application of white fleece-flower root or white fleece-flower root diketone A in the preparation of medicament for treating neurological disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Take 10 mg of cynandione A (Diketone A of Polygonum multiflorum), dissolve it in an appropriate amount of water for injection, add 200 mg of mannitol, and freeze-dry according to the conventional freeze-drying process to obtain the freeze-dried powder for injection. For the treatment of various neurodegenerative diseases. According to the aforementioned dose and course of treatment, it has obvious therapeutic effect.

Embodiment 2

[0074] The total extract of Radix Polygoni Multiflori is dispersed with an appropriate amount of water for injection, spray-dried or vacuum-dried to obtain the dry powder of Radix Polygoni Multiflori, take polyethylene glycol 400, add the dry powder of Radix Polygoni Multiflori, stir until uniform while adding, and use the pressing method to prepare into soft capsules. For the treatment of various neurodegenerative diseases. According to the aforementioned dose and course of treatment, it has obvious therapeutic effect.

Embodiment 3

[0076] Take 10mg of cynandione A (Baishouwu diketone A), disperse it with appropriate amount of water for injection, add appropriate amount of excipients, mix well, make granules, dry, press into 1000 tablets, and coat sugar-coated to get Baishouwu acetophenone tablets. For the treatment of various neurodegenerative diseases. According to the aforementioned dose and course of treatment, it has obvious therapeutic effect.

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Abstract

The invention pertains to the art of medical technology, in particular to an application of cynanchum bunaei or cynanchum bunaei diketone A in preparing drugs for the prevention and cure of various neurodegenerative diseases (particularly senile dementia). The cynanchum bunaei is a dry root of Asclepiadaceae vine plants such as ear-leaved swallowwort, Viola betonicifolia swallowwort and auriculate swallowwort root. The cynanchum bunaei diketone A is an Acetophenone compound separated from the cynanchum bunaei; the formula is C16H14O6 and the molecular weight is 302.28. Experimental study finds that the cynanchum bunaei or cynanchum bunaei diketone A have significant protective effects on primary rat nerve cells and PC 12 cell injuries as well as adult mouse brain injuries induced by glutamate and A Beta. The clinical observation shows that the cynanchum bunaei or cynanchum bunaei diketone A significantly stabilize and improve the conditions of senile dementia patients, which can be used for preparing drugs for the prevention and cure of various neurodegenerative diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an application as a drug for preventing and treating various neurodegenerative diseases (especially senile dementia). Baishouwu and cynandioneA (Baishouwudione A). Background technique [0002] Neurodegenerative diseases include senile dementia (Alzheimer's disease), Parkinson's disease, Huntington's disease, and the like. With the aging of the population, the incidence of neurodegenerative diseases, especially senile dementia, is increasing day by day, which has become one of the major problems of human public health. Drugs for the prevention and treatment of Alzheimer's disease include cholinergic precursors, cholinesterase inhibitors, cholinergic agonists, catecholamines, serotonergic drugs, various types of neurotransmitters, and neuropeptides opioid antagonists (eg, naloxone), antioxidant and neuroprotective agents, neurotrophic agents, hormones (eg, tacrine, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K31/12A61K9/02A61K9/06A61K9/08A61K9/10A61K9/107A61K9/14A61K9/16A61K9/20A61K9/48A61P25/14A61P25/16A61P25/28A61K125/00
Inventor 张卫东单磊张川何成苏娟肖林沈云亨
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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