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A fabrication method of a localized surface plasmon biochemical sensor

A biochemical sensor, plasma technology, applied in instruments, scientific instruments, biological testing, etc., can solve the problems of single micro-nano structure, small binding area, reduced detection efficiency and sensitivity, etc., to achieve easier combination, increase in number, and improve detection. Effects of Efficiency and Sensitivity

Active Publication Date: 2012-02-22
INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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Problems solved by technology

However, there are problems such as a single micro-nano structure that excites localized surface plasmon resonance, and a small binding area, which reduces the detection efficiency and sensitivity.

Method used

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  • A fabrication method of a localized surface plasmon biochemical sensor
  • A fabrication method of a localized surface plasmon biochemical sensor

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Embodiment Construction

[0023] The present invention will be described in detail below with reference to specific embodiments and drawings, but the scope of protection of the present invention is not limited to the following embodiments, and should include all the content in the claims. Moreover, those skilled in the art can realize all the content in the claims from the following embodiment.

[0024] The specific process of the embodiment of the present invention is as follows:

[0025] (1) Select the substrate material according to the needs of the transmission wavelength, which can be visible light material glass, quartz, infrared material germanium, silicon, and clean the substrate with concentrated sulfuric acid and ammonia, and then dry it with nitrogen;

[0026] If the diameter of the nanospheres used in the production process can be compared with the wavelength of visible light, the transmission wavelength is within the range of visible light, and the substrate material can be glass, quartz, etc. If...

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Abstract

A method for manufacturing a local surface plasmon biochemical sensor, the steps are as follows: (1) select a substrate material according to the transmission wavelength, and clean and dry the substrate; (2) place the cleaned substrate flat on a horizontal surface, Then uniformly assemble a layer of nanospheres; (3) after the assembled nanospheres are dried, evaporate a layer of metal on the assembled balls and the substrate, and then dry them with nitrogen; (4) according to the composition of the substrate and the nanospheres Characteristics of Refractive Index Choose glue with different refractive index to spin-coat on the metal surface, and then dry, which completes the production of the sensor. The local surface plasmon (LSPR) waves produced by the two layers of silver nanoparticles of the present invention interact with each other to make the transmittance more uniform; and this micro-nano structure can be used as the substrate of biological samples, making it easier for biomolecules to combine, Thereby improving the detection efficiency and sensitivity of the nanosensor.

Description

Technical field [0001] The invention relates to a method for manufacturing a novel localized surface plasma biochemical sensor using a mixed metal structure. Background technique [0002] Biosensors are a very active field of research and engineering technology. Together with bioinformatics, biochips, biological cybernetics, bionics, biocomputers and other disciplines, they are in the intersection of life sciences and information sciences. Their common characteristics are: exploring and revealing the basic laws of information generation, storage, transmission, processing, conversion, and control in life systems, and exploring the basic methods applied to human economic activities. The research focus of biosensor technology is: the extensive application of various bioactive materials in combination with sensors, the research and development of transducers with recognition functions, and the creation of original technologies for the manufacture of new analytical instruments and ana...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/50G01N21/55G01N21/552
Inventor 罗先刚朱少丽杨欢杜春雷
Owner INST OF OPTICS & ELECTRONICS - CHINESE ACAD OF SCI
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