Collagen produced accelerant, dressing material, and method for producing collagen

A technology for cosmetic materials and manufacturing methods, which is applied in the direction of cosmetic preparations, cosmetics, preparations for dressing, etc., and can solve the problems of promoting collagen production without polyphosphoric acid

Active Publication Date: 2008-04-02
REGENETISS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant record that polyphosphoric acid promotes collagen production

Method used

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  • Collagen produced accelerant, dressing material, and method for producing collagen
  • Collagen produced accelerant, dressing material, and method for producing collagen
  • Collagen produced accelerant, dressing material, and method for producing collagen

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0073] [Manufacturing example 1] Preparation of sodium polyphosphate

[0074] Sodium polyphosphates of various chain lengths were prepared as described below. (i) 200 g of food additive standard sodium hexamethylphosphate (manufactured by Taihei Chemical Industry Co., Ltd.) was dissolved in 1,000 ml of purified water, and 50 ml of 96% ethanol was slowly added thereto. (ii) The obtained solution was stirred well, left to stand at room temperature for 1 hour or more, and then centrifuged (10,000×g, 10 minutes, 25° C.) to separate the liquid into two layers. (iii) Take out the upper layer and move it to another container. (iv) The lower layer containing high-molecular-weight (long-chain) sodium polyphosphate is collected and stored as a fraction (fraction 1) containing long-chain sodium polyphosphate with the largest molecular weight.

[0075] (v) Further add 50 ml of ethanol to the upper layer that has just been separated and recovered by the operation of (iii). The operation...

Embodiment 1

[0078] Determining the Average Molecular Weight and Molecular Weight Range of Sodium Polyphosphate

[0079] As a result of the above separation operation, each fraction was divided into three groups and mixed, and each group was made into long-chain sodium polyphosphate, medium-chain sodium polyphosphate, and short-chain sodium polyphosphate. The group of mixed fractions 1 and 2 is long-chain sodium polyphosphate, the group of mixed fractions 3-5 is medium-chain sodium polyphosphate, and the group of mixed remaining fractions 6-9 is short-chain sodium polyphosphate. Moreover, the group which mixed all the fractions 1-9 was made into the split sodium polyphosphate containing all molecular weights and having a large molecular weight distribution. The mixture of each of the above fractions was freeze-dried, and ethanol was completely removed to obtain sodium polyphosphate powders of each chain length. The average chain length and molecular weight distribution of each group were ...

Embodiment 2

[0099] Confirmation of the properties of sodium superphosphate

[0100] Regarding the sodium superphosphate used in this example, it is known as its molecular characteristics that when it is made into an aqueous solution, it shows a strong acidity of pH 1 to 2, and when it is titrated with an alkaline solution such as sodium hydroxide, it becomes acidic at the above pH. The regions have pH buffered regions. Proceeding from this fact, the sodium superphosphate aqueous solution was titrated with the sodium hydroxide aqueous solution, and the pH change thereof was measured, as shown in FIG. 2 . As a result, buffering action was exhibited around pH 1 to 2, and it was confirmed that it had properties of sodium superphosphate.

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PUM

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Abstract

The object of the present invention is to provide an agentia and a face-painting material which can accelerate the generation of the collagen, and a producing method using the agentia, wherein, the raw materials of the agentia and the face-painting material which can accelerate the generation of the collagen can be easily obtained and the biosome thereof has excellent affinity. The object can be solved by the agentia which contains the polyphosphoric acids, the salt or solvate thereof as effective ingredient and can accelerate the generation of the collagen, the face-painting material containing the agentia, and a collagen producing method including the step of giving the polyphosphoric acids, the salt or solvate thereof to the human or mammal.

Description

technical field [0001] The present invention relates to a collagen production accelerator containing polyphosphoric acid as an active ingredient, a method for producing collagen, and an applied product thereof. Background technique [0002] In aging skin, as the activity of fibroblasts decreases, collagen fibers, elastin fibers, and acidic mucopolysaccharides, which are components of the dermal matrix, undergo qualitative and quantitative changes. Collagen fibers are originally elastic fibers. However, as the body ages, cross-links are formed in the collagen fibers, so the collagen fibers lose their elasticity. As a result, one's skin loses its suppleness, wrinkles and sags. In order to prevent such aging of the skin, collagen production promoters have been disclosed (Japanese Patent Application Laid-Open No. 11-335293, Japanese Patent Laid-Open No. 2000-191498, Japanese Patent Laid-Open No. 2000-309521, Japanese Patent Laid-Open No. 2001-316240 , Japanese Patent Laid-Ope...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/84A61K8/02A61K31/80A61P17/16A61Q19/00
CPCA61K8/02A61K8/042A61K8/06A61K8/24A61K8/55A61Q19/08
Inventor 柴肇一加藤真一川添祐美
Owner REGENETISS
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