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Medicament gelling agent for treating prostatitis and chronic pelvic inflammatory disease, and method for preparing the same

A technology for chronic pelvic inflammatory disease and prostatitis, which is applied in the direction of medical formula, drug combination, drug delivery, etc. It can solve the problems of suppository melting and easy outflow, poor mucoadhesion, and low bioavailability, so as to prolong the residence time and effect Fast, highly bioavailable effect

Inactive Publication Date: 2008-04-02
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many medicines for treating such diseases on the market, and the medicines for internal use are more or less harmful to the stomach, and the effect is not good because of the first-pass effect of the liver. Most of the medicines for external use are suppositories, which mainly have the following disadvantages: suppositories It melts and flows out when used, is greasy, has a short residence time in the rectum, has poor mucoadhesive effect, is inconvenient to use, feels uncomfortable due to foreign body sensation, and has low bioavailability, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 200g of wild chrysanthemum, 8g of propylene glycol, 1.5g of carbomer, 0.5g of polysorbate 80 and 0.1g of sorbic acid.

[0037] Take the above amount of wild chrysanthemum, add 10 times the amount of water to decoct for 2 hours for the first time, add 6 times the amount of water for the second time, decoct for 1 hour, add 6 times the amount of water for the third time, decoct for 40 minutes and combine the decoction, filter After filtration, the filtrate is concentrated to a clear paste with a relative density of 1.10 (50-60°C), adding ethanol to make the alcohol content 60%, standing still, taking the supernatant, reclaiming the ethanol and concentrating to a relative density of 1.17 (50°C) Add ethanol to make the alcohol content 80%, let it stand, take the supernatant, reclaim ethanol, and concentrate into a thick paste (about 16g), add Carbomer 940 in purified water and stir evenly, and swell After 24 hours, add triethanolamine to adjust the pH to 6-8.5, add pro...

Embodiment 2

[0039] Weigh 200g of wild chrysanthemum, 25g of propylene glycol, 2g of carbomer, 3g of polysorbate 80 and 0.2g of sorbic acid.

[0040] Take the above amount of wild chrysanthemum, add 10 times the amount of water to decoct for 2 hours for the first time, add 6 times the amount of water for the second time, decoct for 1 hour, add 6 times the amount of water for the third time, decoct for 40 minutes and combine the decoction, filter After filtration, the filtrate is concentrated to a clear paste with a relative density of 1.10 (50-60°C), adding ethanol to make the alcohol content 60%, standing still, taking the supernatant, reclaiming the ethanol and concentrating to a relative density of 1.17 (50°C) Add ethanol to make the alcohol content be 80%, let it stand, take the supernatant, reclaim the ethanol, and concentrate into a thick paste (about 16g), add Carbomer 940 in purified water and stir evenly, and swell for 24 Add triethanolamine to adjust the pH to 6-8.5, add propylen...

Embodiment 3

[0042] Weigh 200g of wild chrysanthemum, 5g of propylene glycol, 0.8g of carbomer, 0.5g of polysorbate 80 and 0.1g of sorbic acid.

[0043] Take the above amount of wild chrysanthemum, add 10 times the amount of water to decoct for 2 hours for the first time, add 6 times the amount of water for the second time, decoct for 1 hour, add 6 times the amount of water for the third time, decoct for 40 minutes and combine the decoction, filter After filtration, the filtrate is concentrated to a clear paste with a relative density of 1.10 (50-60°C), adding ethanol to make the alcohol content 60%, standing still, taking the supernatant, reclaiming the ethanol and concentrating to a relative density of 1.17 (50°C) Add ethanol to make the alcohol content be 80%, let it stand, take the supernatant, reclaim the ethanol, and concentrate into a thick paste (about 16g), add Carbomer 940 in purified water and stir evenly, and swell for 24 Add triethanolamine to adjust the pH to 6-8.5, add propy...

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PUM

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Abstract

The invention discloses a medical gel for remedying the prostatitis and the chronic pelvic inflammation and the preparation method of the medical gel. The invention is characterized in that the medical gel is made from the raw materials with the following weight portion of 200 portion of wild chrysanthemum flowers, 5 to 25 portion of propanediol or 5 to 25 portion of glycerol, 0.5 to 2.0 portion of carbomer or 0.5 to 4 portion of carboxymethylcellulose, 800.1 to 3 portion of polysorbate and 0.05 to 0.2 portion of sorbic acid, and the rest is distilled water. The invention has the characteristics of being not greasy to be uniformly applied and spread and well absorbed, good compatibility without stimulation, high biological utilization degree, good stability and little adverse reaction.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine prescription preparations, and specifically relates to a drug gel for treating prostatitis and chronic pelvic inflammatory disease, and also relates to a preparation method thereof. Background technique [0002] Prostatitis is a common and frequently-occurring disease in male adults. Its onset is slow, its etiology is complicated, its course is protracted, and its nature of disease is recurrent and difficult to heal, which affects the life and study of patients. Chronic pelvic inflammatory disease is also a common gynecological frequently-occurring disease. At present, there are many medicines for treating such diseases on the market, and the medicines for internal use are more or less harmful to the stomach, and the effect is not good because of the first-pass effect of the liver. Most of the medicines for external use are suppositories, which mainly have the following disadvantages: s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/00A61K47/34A61K47/38A61P13/08A61P15/00A61K47/26
Inventor 董大伦
Owner GUIYANG XINTIAN PHARMA CO LTD