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Peony leaves total glycoside extract, its preparation method and application

A technology of peony leaves and extracts, which is applied in the field of research and development of new traditional Chinese medicines, can solve the problems of few peony leaves and no effective parts for separation, and achieve the effect of simple process and high content

Active Publication Date: 2011-07-20
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are very few studies on the chemical constituents and pharmacological activities of Moutan leaves, and there is no literature report on the extraction and isolation of effective parts from Moutan leaves

Method used

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  • Peony leaves total glycoside extract, its preparation method and application
  • Peony leaves total glycoside extract, its preparation method and application
  • Peony leaves total glycoside extract, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: The preferred preparation method of the total glycosides extract of Moutan leaves

[0083] Take peony leaf medicinal material powder, heat and reflux extraction with 14 times of medicinal material volume 50% ethanol for 3 times, each time for 1 hour. Filter, recover ethanol from the ethanol extract under reduced pressure at 60°C, concentrate the extract to an extract with a relative density of 1.20 (measured at 25°C), add 5 times the weight of the medicinal material in water (60°C) to dissolve the extract, centrifuge, and The supernatant was passed through the ZTC-1 resin column, washed with water 4 times the resin volume (V / W) and 5% ethanol 5 times the resin volume (V / W) to remove unadsorbed impurities in the column, and then washed with 6 Desorb with 40% ethanol twice the resin volume (V / W). The desorbed solution was collected, concentrated under reduced pressure, and dried in vacuum to obtain the total glycosides extract of Moutan Folium, wherein the con...

Embodiment 2

[0084] Example 2: The preferred preparation method of total glycosides extract of Moutan leaves

[0085] Take peony leaf medicinal material powder, heat and reflux extraction twice with 95% ethanol of 8 times the medicinal material amount, each time for 1 hour. Filter, recover ethanol from the ethanol extract under reduced pressure at 60°C, concentrate the extract to an extract with a relative density of 1.20 (measured at 25°C), add 10 times the weight of the medicinal material in water (60°C) to dissolve the extract, centrifuge, and Clear liquid passes through D101 resin column, with 6 times of resin volume (V / W) water and 10% ethanol of 2.5 times of resin volume (V / W), wash away the unadsorbed impurity in column, then wash with 10 times of resin volume (V / W) Resin volume (V / W) was desorbed with 20% ethanol. The desorption solution was collected, concentrated under reduced pressure, and dried in vacuum to obtain the total glycosides extract of Moutan Folium, wherein the cont...

Embodiment 3

[0086] Example 3: The preferred preparation method of total glycosides extract of Moutan leaves

[0087] Take peony leaf medicinal material powder, use 10 times of medicinal material volume 80% ethanol, percolate and extract. Recover ethanol from the ethanol extract under reduced pressure at 60°C, concentrate the extract to an extract with a relative density of 1.20 (measured at 25°C), add 8 times the weight of the medicinal material in water (60°C) to dissolve the extract, centrifuge, and the supernatant Through the DM301 resin column, wash away unadsorbed impurities in the column with water 10 times the volume of the resin (V / W) and 20% ethanol 2 times the volume of the resin (V / W), and then use 4 times the volume of the resin (V / W) 60% ethanol desorption. The desorbed solution was collected, concentrated under reduced pressure, and vacuum-dried to obtain the total glycosides extract of Moutan Folium, wherein the content of total glycosides of Moutan Folium was 85%, and the...

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Abstract

The present invention provides a moutan leaf total glucoside extract which is separated from new medicinal portion of moutan leaf and is purified and its preparation method. In the concrete, the total glucoside content in the described moutan leaf total glucoside extract is 50%-95%, in which the paeoniflorin content is 45%-95%. Said invention also provides the application of moutan leaf total glucoside extract in preparation of medicines for curing diabetes and coronary heart disease.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. The invention relates to an effective part isolated from new medicinal parts of Chinese medicinal materials, and provides its preparation method and medical use. Background technique [0002] Peony is not only an ornamental plant, it can also be used as a medicinal plant. The 2005 edition of "Chinese Pharmacopoeia" recorded Moutan Cortex (also known as Cortex Moutan) as a legal Chinese medicinal material. Cortex Moutan is the dried root bark of Paeonina suffruticosa Andr. in the family Ranunculaceae. At present, there are many researches on the chemical components and effective parts of Cortex Moutan. According to literature reports, Moutan Cortex mainly contains paeonol, paeonol glycoside, paeonol protoside, paeonol neoside, paeoniflorin, hydroxypaeoniflorin, benzoylpaeoniflorin, benzoylhydroxypaeoniflorin, gallic acid, volatile oil , inorganic ele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61P3/10A61P9/10
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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