Composition for preparing plant hollow hard capsule and preparation method of capsule

A technology of hollow hard capsules and hollow plants, which can be used in capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc. It can solve the problems of high production costs, achieve good temperature and humidity changes, increase toughness, and good stability Effect

Active Publication Date: 2008-04-30
北京长征天民高科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Considering it comprehensively, i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1) 2.4 kilograms of plasticizer (glycerol) are dissolved in 19.2 kilograms of water;

[0046] 2) Add 2.0 kg of coagulant (τ-carrageenan) to the aqueous solution obtained in step 1);

[0047] 3) Heating the mixed solution in step 1) with a water bath at 85° C. to dissolve all the solid substances therein, then add 25 kg of filler (hydroxypropyl methylcellulose), and stir evenly;

[0048] 4) Cool down the mixed solution naturally, add 3 kg of defoamer (ethanol) for defoaming during this process, and keep the glue at a constant temperature when the temperature is lowered to 53°C;

[0049] 5) Place the glue solution in a immersion tank, dip the glue solution at a temperature of 50° C., and make the required hollow capsules after drying, demoulding, cutting and fitting.

Embodiment 2

[0051] 1) 4 kilograms of plasticizers (glycerin) are dissolved in 90 parts by weight of water;

[0052] 2) Add 4 kg of coagulant (τ-carrageenan: κ-carrageenan=8:2) to the aqueous solution obtained in step 1);

[0053] 3) Heating the mixed solution in step 1) with a water bath at 95°C to dissolve all the solid substances therein, then add 60 kg of filler (hydroxypropyl methylcellulose), and stir evenly;

[0054] 4) Cool down the mixed solution naturally, add 10 kg of defoamer (ethanol) for defoaming during this process, and cool down to 53°C to keep the rubber at a constant temperature;

[0055] 5) Place the glue solution in a immersion tank, dip the glue solution at a temperature of 50° C., and make the required hollow capsules after drying, demoulding, cutting and fitting.

Embodiment 3

[0057] 1) Dissolve 4 kg of plasticizer (glycerol) in 90 kg of water;

[0058] 2) Add 4 kg of coagulant (κ-carrageenan) to the aqueous solution obtained in step 1;

[0059] 3) Heating the mixed solution in step 1) with a water bath at 90°C to dissolve all the solid substances therein, and then add 60 kg of fillers (hydroxypropyl methylcellulose, ethyl cellulose, carboxymethyl cellulose One of them or a mixture of any two of them), stir evenly;

[0060] 4) Cool down the mixture naturally, add 10 kg of defoamer (ethanol) for defoaming during this process, and keep the rubber at a constant temperature when the temperature is lowered to 53°C;

[0061] 5) Place the glue solution in a immersion tank, dip in the glue solution at a temperature of 45° C., dry, demould, cut and fit to make the required hollow capsules.

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Abstract

The invention relates to a composition for preparing plant hollow hard capsules and a preparation method of the capsules. In parts by weight, the composition includes: 2-10 parts of coagulant, 40-60 parts of filler, 1-20 parts of plasticizer, 2-15 parts of defoamer and 10-100 parts of water. The composition may also include 0.02-1 parts by weight of coagulant aid and/or 1-5 parts by weight of dispersant. The present invention also relates to a preparation process for preparing a plant-derived hard hollow capsule from the above-mentioned composition for preparing a plant-derived hard hollow capsule. Compared with the prior art, the advantages of the formula and production process of the present invention are that the transparency of the product and the glossiness of the capsule surface are also increased, so that the capsules made are more aesthetically pleasing; the capsules obtained by the present invention have good stability and can Adapts well to changes in temperature and humidity.

Description

technical field [0001] The invention relates to a hollow capsule, in particular to a composition for preparing a plant hollow hard capsule and a preparation method of the hollow hard capsule. Background technique [0002] Hollow hard capsules are a very important dosage form in capsules, and have been more and more widely used with the development of medical science and technology. [0003] The main raw material of traditional hollow hard capsules is gelatin, and gelatin is extracted from the skins and bones of animals such as pigs, cattle, and sheep. This has limited its application in certain religious groups, coupled with the spread of animal-borne diseases such as mad cow disease and foot-and-mouth disease in Europe, people have questioned the safety of gelatin, in addition to gelatin also has other The shortcomings that are difficult to overcome, such as gelatin is easy to react with compounds containing aldehyde groups, resulting in aging of the capsule shell, thereby...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/02A61K47/10A61K47/26A61K47/36A61K47/38
Inventor 石海峰宁周云
Owner 北京长征天民高科技有限公司
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