Chemically synthesized HSV1 virus gB glucoprotein extracellular region gene fragment, representation and application of the same
Patent Information
- Authority / Receiving Office
- CN Β· China
- Current Assignee / Owner
- ζθΆεΈ
- Publication Date
- 2008-05-07
- Estimated Expiration
- Not applicable Β· inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to a chemically synthesized brand-new gene fragment of the extracellular region of herpes simplex virus 1 (Herpes simplex virus 1, HSV1) glycoprotein B (glycoprotein B, gB glycoprotein), and uses genetic engineering technology to prepare recombinant HSV1 virus gB glycoprotein. Through computer analysis, the gB glycoprotein extracellular region fragment of HSV1 virus containing strong antigenic epitopes is screened out, the codons favored by both eukaryotic and prokaryotic organisms are selected, and a new gene sequence is chemically synthesized, and expressed by genetic engineering technology. The protein can be used for the detection of vaccines and HSV1 virus antibodies or antigens, etc. The invention relates to the fields of genetic engineering technology, vaccines and diagnostic reagents. Background technique
[0002] Herpes simplex virus (HSV) is a common pathogen that endangers human health. It is easy to cause recu...