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A novel inter and intra multilamellar vesicular composition

A technology for multi-layer vesicles and products, applied in the field of drug delivery, can solve the problems of low staining and low dispersion, and achieve the effect of improving patient compliance

Inactive Publication Date: 2008-05-14
LIFECARE INNOVATIONS PVT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This composition exhibits low dyeability but very low dispersibility

Method used

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  • A novel inter and intra multilamellar vesicular composition
  • A novel inter and intra multilamellar vesicular composition
  • A novel inter and intra multilamellar vesicular composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0107] The composition of the obtained dithranol liposome product

[0108] serial number

component name

In every 20gm product

Amount of ingredients contained

%w / w

1

Dithranol

100mg

0.5

2

Phospholipids

2.0gm

10.0

3

cholesterol

1.0gm

5.0

4

Butylated Hydroxytoluene (Antioxidant)

60.0mg

0.3

5

Methylcellulose

400mg

1.0-2.0

6

USP Pharmaceutical Grade Phosphate Buffered Saline at pH 6.4

Contains 0.5% w / w sodium metabisulfite (antioxidant)

q.s.20.0gm

(q.s.: sufficient quantity)

[0109] parameter

value

Dithranol per Whole Product

0.5%w / w

Dithranol: total lipid (weight ratio)

100mg drug: 3000mg total fat

Dithranol as a percentage of total lipids

3.33% of total fat

intralaminar (intravesicular) dithranol

70.2% of the total dosage

interlaminar (int...

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Abstract

The present invention is related to the development of a novel inter and intra multilamellar vesicular composition containing an antipsoriatic drug dithranol. The exquisitely structured mesophase made up of saturated phospholipids (which have an inherent antioxidant property and protect the lipid soluble molecules) at the micro range level improve the overall performance of the drug by way of modifying and controlling the release as well as the reactivity of the drug. Further, such microstructured system in conjunction with hydrocolloid gel makes the system rheologically more acceptable. Thus, the formulation so developed tends to make the drug molecules effective at a reduced dose level, non-irritant, non-staining, easily applicable (stays on the affected site) and stable as well. Besides this, there is an added advantage allowing an enhanced application time vis-vis the short contact therapy presently practiced. Also, the formulation developed has the potential to incorporate an increased dose level of the drug without any irritancy and staining where the severity of disease demands so. Thus, the product has improved the dithranol therapy along with some additive advantageous features.

Description

technical field [0001] The present invention relates to the field of drug delivery in which drug molecules are contained in different layers within the system of the invention (enveloped or non-enveloped) to allow optimal delivery to the target site. The drug delivery system of the present invention is constructed by selecting suitable components of various physicochemical properties and designing these components in a conformational pattern suitable for the purpose. The present invention is suitable for the administration of dermatological diseases such as psoriasis, where the anthranol drug is delivered in the germinal layer of the epidermis by means of in situ generation of microstructures with the help of biofriendly and most appropriate components conduct. Background technique [0002] Dithranol is a drug of choice for topical treatment of psoriasis and many other dermatological conditions over other psoriasis treatments such as corticosteroids because of prolonged rem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127
CPCA61K9/127A61K31/74A61K9/0014A61K9/06A61P17/00A61P17/06A61P17/08
Inventor 欧姆·普拉卡什·卡塔热拉文德拉·阿加瓦普山·库玛
Owner LIFECARE INNOVATIONS PVT LTD
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