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Chinese peony and glycyrrhiza uralensis extract and its application in preparing medicine for treating irritable bowel syndrome

A technology of irritable bowel syndrome and licorice extract, which is applied in the field of medicine, can solve the problems of insufficient verification of therapeutic drugs, slow gastric motility, and slow small intestinal propulsion speed

Inactive Publication Date: 2008-06-04
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In previous pharmacodynamic studies on Radix Paeoniae Alba extract (Chinese patent: ZL 02156681X), the inventor mentioned that Radix Paeoniae Alba extract can significantly reduce gastric acid secretion, total acidity of gastric juice and total acid excretion, and make pepsin Activity obviously reduces, and protection gastric mucosa (referring to pharmacological experiment five), suggests that it can be used as the application of the medicines such as gastric ulcer, gastritis, gastric digestive dysfunction; Empty, slow gastric motility, slow down small intestine propulsion speed (see pharmacological experiment 2), but this is not enough to verify that it can be used as a therapeutic drug for gastrointestinal motility disorders, especially in IBS diseases app doesn't mention

Method used

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Embodiment Construction

[0008] Aiming at the main pathogenesis of irritable bowel syndrome, the present invention studies the effects of Radix Paeoniae Alba extract on animal models of abnormal gastrointestinal motility (sick animals) and the movement of small intestinal smooth muscle caused by different media. The research results prove that Radix Paeoniae Alba Gan extract has obvious regulating effect on the disorder of gastrointestinal smooth muscle motility, and can be used to treat IBS.

[0009] The Radix Paeoniae Alba extract used in the present invention is prepared by the method of ZL 02156681.X.

[0010] The effect of Paeoniae Radix Paeoniae Alba extract on gastrointestinal motility is illustrated through specific experiments related to the treatment of IBS.

[0011] Preparation of the nutritional semi-solid paste used in the experiment: Take 10g of sodium carboxymethylcellulose, dissolve it in 250ml of distilled water, add 16g of milk powder, 8g of sugar, 8g of starch and 2g of activated ca...

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Abstract

The invention uses plenty of specific pharmacological experiments to confirm that paeonia and licorice root extracts can regulate motor function disorder of the smooth muscles of the intestine and the stomach, thus indicating paeonia and licorice root extracts and the preparations thereof can be prepared into drugs for treating irritable bowel syndrome.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a new medical application of the extract of Paeoniae Radix and Glycyrrhizae, in particular to the application of the extract of Paeoniae Radix Glycyrrhizae in preparing medicine for treating irritable bowel syndrome. technical background: [0002] Irritable bowel syndrome (irritable bowel syndrome, IBS) is a gastrointestinal motility disorder, mainly manifested as generalized gastrointestinal dynamic hyperactivity, is one of the most common digestive system diseases, accounting for about 100% of normal people. 9% to 26%, accounting for more than 1 / 3 of gastrointestinal outpatient clinics. This is actually a group of chronic or intermittent upper gastrointestinal syndrome without organic causes. Symptoms are: epigastric or retrosternal pain or discomfort, heartburn, nausea, vomiting, or other symptoms related to the upper abdominal gastrointestinal tract, which last for more than 4 weeks...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/02A61K9/08A61K9/107A61K9/14A61K9/20A61K9/48A61P1/00
Inventor 徐文豪郑礼蒋晖苑可武白芳凌海燕
Owner BEIJING INCREASEPHARM CORP LTD