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Method for producing 4-hydroxyindole

A technology of oxindole and indole, which is applied in the field of preparing 4-oxindole, can solve the problems of no 4-oxindole industrial production technology, and achieve the effects of strong market competitiveness, low production cost and high yield

Active Publication Date: 2008-06-11
CHANGZHOU SUNLIGHT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] It is understood that there are very few industrialized manufacturers of 4-hydroxyindole in China at present, most of which are produced in small batches, and there is no industrialized production technology for 4-hydroxyindole

Method used

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  • Method for producing 4-hydroxyindole

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Experimental program
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Effect test

Embodiment 1

[0021] 20kg4-oxoindole, 4kg Pd content is 5% Pd / C catalyst (palladium charcoal catalyst), 60L diethylene glycol dimethyl ether is made solvent in the reaction kettle of 100L band agitator, and is passed to the reaction kettle interlayer. Enter steam to heat up the temperature, start stirring, and carry out catalytic dehydrogenation reaction under the condition of T=150~160°C. After the dehydrogenation reaction is finished, filter to separate the Pd / C catalyst, the separated Pd / C catalyst can be recycled, and the separated filtrate is pumped into a 100L distillation still for vacuum distillation to collect diethylene glycol dimethyl ether Fractions (can continue to be applied mechanically), and then collect 11kg of product fractions, the mass yield is 55%, and the content: ≥99.0%.

Embodiment 2

[0023] Other conditions are identical with embodiment 1, just change diethylene glycol dimethyl ether into diethylene glycol monomethyl ether. 10.6 kg of the product (4-oxindole) was obtained, the mass yield was 53%, and the content: ≥99.0%.

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Abstract

The invention relates to a preparation method of 4-hydroxyindole, belonging to fine chemistry technical field, which processes catalysis dehydrogenation on 4-hydroxyindole in catalyst and alcohol ether solvent, and distills the product to obtain product 4-hydroxyindole. The invention is characterized in utilized catalysis dehydrogenation, with low production cost, little environment pollution, high product quality, high yield, strong competence in market and industry application suitability.

Description

Technical field [0001] The invention relates to a method for preparing 4-oxindole, which belongs to the technical field of fine chemicals. Background technique [0002] 4-Hydroxyindole is a high value-added fine organic chemical product, which is mainly used in the fields of pharmaceutical chemical industry and daily chemical industry. [0003] It is known that there are very few industrial manufacturers of 4-hydroxyindole in China at present, most of which are produced in small batches, and there is no industrial production technology of 4-hydroxyindole. Contents of the invention [0004] In order to overcome the deficiencies of the 4-hydroxyindole industrial production method, the object of the invention is to provide a method for preparing 4-hydroxyindole with low production cost, simple aftertreatment, less environmental pollution, good product quality and high yield. It is more conducive to industrial promotion. [0005] The technology and scheme adopted in the pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/32
Inventor 胡国宜闵雪锋薛建伟
Owner CHANGZHOU SUNLIGHT PHARMA