Preparation of tamoxifen citrate microcapsule prepared by complex coacervation method

Abstract

The invention relates to a complex coacervation method for preparing the tamoxifen citrate microcapsule, the steps include: (1) the capsule core tamoxifen citrate is weighed and dissolved in 95 percent of ethanol for ultrasonic dissolution, Arab gum solution is added, the mixture is treated ultrasonically in a water bath, then the gel water solution is added, and the water bathing and stirring are carried out to control the weight ratio of the capsule core and the capsule material; (2) 10 percent of glacial acetic acid is added to adjust the pH value to 4.0 to 4.3 during the stirring process, distilled water is added for dilution, the high-speed stirring is carried out, then the mixture is arranged in an ice bath for rapid temperature-decreasing to 0 to 10 DEG C, and crosslinker is added for curing; (3) 20 percent of NaOH solution is used for adjusting the pH value, the high-speed stirring is carried out at 0 to 10 DEG C, and the tamoxifen citrate microcapsule can be obtained by curing, centrifugalizing, washing, freezing, decompression and drying. The method is simple, safe and good in reproducibility, and the prepared microcapsule is proved to have the better sustained-release function by transdermal and in vitro dissolution results, so the invention can be taken as the drug sustained-release formulation for the prevention and treatment of breast cancer.

Description

technical field [0001] The invention belongs to the field of preparing pharmaceutical preparations for preventing and treating breast cancer, in particular to a preparation method of tamoxifen citrate microcapsules. Background technique [0002] In recent years, the incidence of breast cancer has increased dramatically. In Western countries, breast cancer has become the number one cause of death among women. In recent years, the incidence of breast cancer in my country has also been on the rise. According to the latest report from the health department, the incidence of breast cancer has become the No. It still ranks 9th among tumor diseases. In recent years, there are about 1.6 million to 1.8 million new cancer patients in my country every year, and the total number of cancer patients is about 4.5 million to 6 million. [0003] At present, the main means of breast cancer treatment include: surgery, radiotherapy, chemotherapy and endocrine therapy. Among them, endocrine...

AI Technical Summary

Problems solved by technology

But so far, the dosage form of tamoxifen citrate is mainly tablets, which have the disadvantages of short drug release time and great gastrointestinal irritation.

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