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Digitalis extract and preparation thereof

A technology for extracting digitalis, applied in the field of digitalis total glycosides in digitalis and its preparation, can solve the problems of extracting digitalis and not mentioning it, and achieve the effect of simple operation, high content and low cost

Active Publication Date: 2012-05-23
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no mention of how to extract digitalis from digitalis leaves in the art

Method used

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  • Digitalis extract and preparation thereof
  • Digitalis extract and preparation thereof
  • Digitalis extract and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Add 6 L of 70% ethanol aqueous solution to 1 kg of digitalis leaf meal, and extract under reflux at 60° C. for 60 minutes. Add 6L of 70% ethanol to the residue and extract under reflux at 60°C for 60 minutes, and combine the extracts. The resulting extract was concentrated under reduced pressure until the alcohol content was 20%, and then placed in a 4°C refrigerator overnight, filtered the next day, and after the supernatant was concentrated to remove ethanol, use one-third of the amount (based on the volume of the solution to be extracted, the next Same) petroleum ether extraction once. The water layer was recovered to dryness under reduced pressure, dissolved in 20% ethanol, extracted three times with one-third of the amount of ethyl acetate each time, and the ethyl acetate layers were combined. After the obtained ethyl acetate layer was concentrated to 800ml, the ethyl acetate layer was extracted with 80ml of 10% NaOH solution for 8 times, and then extracted once w...

Embodiment 2

[0073]Add 8 L of 80% ethanol aqueous solution to 1 kg of digitalis leaf coarse powder, and extract under reflux at 60° C. for 90 minutes. Add 8 L of 80% ethanol to the residue and extract under reflux at 60°C for 90 minutes, and combine the extracts. The resulting extract was concentrated under reduced pressure until the alcohol content was 20%, and then placed in a 4°C refrigerator overnight, filtered the next day, and after the supernatant was concentrated to remove ethanol, use one-third of the amount (based on the volume of the solution to be extracted, the next Same) petroleum ether extraction once. The water layer was recovered to dryness under reduced pressure, dissolved in 20% ethanol, extracted three times with one-third of the amount of ethyl acetate each time, and the ethyl acetate layers were combined. After the obtained ethyl acetate layer was concentrated to 800ml, the ethyl acetate layer was extracted with 80ml of 10% NaOH solution for 8 times, and then extract...

Embodiment 3

[0075] Add 10 L of 90% ethanol aqueous solution to 1 kg of digitalis leaf coarse powder, and extract under reflux at 60° C. for 120 minutes. The residue was further extracted with 10 L of 90% ethanol under reflux at 60° C. for 120 minutes, and the extracts were combined. The resulting extract was concentrated under reduced pressure until the alcohol content was 20%, and then placed in a 4°C refrigerator overnight, filtered the next day, and after the supernatant was concentrated to remove ethanol, use one-third of the amount (based on the volume of the solution to be extracted, the next Same) petroleum ether extraction once. The water layer was recovered to dryness under reduced pressure, dissolved in 20% ethanol, extracted three times with one-third of the amount of ethyl acetate each time, and the ethyl acetate layers were combined. After the obtained ethyl acetate layer was concentrated to 800ml, the ethyl acetate layer was extracted with 80ml of 10% NaOH solution for 8 ti...

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PUM

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Abstract

The invention provides a common foxglove extract and the preparation method of the common foxglove extract. The invention further provides an eye drop which contains the common foxglove extract.

Description

technical field [0001] The invention relates to a digitalis extract and a preparation method thereof, in particular to digitalis total glycosides in digitalis and a preparation method thereof. Background technique [0002] Digitalis purpurea L. or Digitalis lanata Ehrh. are dried leaves of the Scrophulariaceae plant, and its main components are cardiac glycosides. Modern pharmacological studies have shown that digitalis has a direct effect on the myocardium, can enhance the contractility of the myocardium, and is more obvious to the failing myocardium. At the same time, digitalis can improve blood circulation or directly inhibit the conduction system in the heart, thereby slowing down the heart rate. . Therefore, digitalis can be used to treat congestive heart failure and atrial fibrillation, and has a significant diuretic and detumescent effect on cardiac edema. [0003] At present, there is a kind of aescin digitalis double glycoside eye drops (trade name: Stulln eye dro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/80A61P7/10A61P9/04A61P9/00A61K127/00
Inventor 杨保华雷仕庆高原陈彬华何威之郭雅琦夏凌云
Owner SHANGHAI SINE PHARMA LAB
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