External preparation of essential oil from Bupleurum root

A technology outside Bupleuri and oil, which is applied in the field of Bupleurum volatile oil topical preparations, which can solve the problems of inconvenient administration of Bupleurum volatile oil, and achieve the effects of superior drug efficacy, stable quality, and convenient clinical selection

Inactive Publication Date: 2008-07-23
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide an external preparation of Bupleurum volatile oil, which can overcome the shortcomings of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1: An external preparation of volatile oil of Bupleurum spp., characterized in that it is composed of volatile oil of Bupleurum spp. 8%, auxiliary components of 2%, 30% solvent, 15% surfactant, and 10% transdermal absorption enhancer. , 5% PH regulator and 30% excipients; the auxiliary component is peppermint extract, the solvent is ethanol, the surfactant is sodium lauryl sulfate, and the transdermal absorption enhancer is dimethyl sulfoxide , The PH regulator is diethanolamine, and the excipient is cellulose acetate.

[0018] The dosage form of the above-mentioned Bupleurum volatile oil external preparation is an emulsion.

Example Embodiment

[0019] Example 2: An external preparation of volatile oil of Bupleurum spp., characterized in that it is composed of volatile oil of Bupleurum spp. 9%, auxiliary components of 6%, 20% solvent, 20% surfactant, and 5% transdermal absorption enhancer. , 5% PH regulator and 35% excipient composition. The auxiliary component is peppermint extract, the solvent is propylene glycol, the surfactant is sodium lauryl sulfate, the transdermal absorption enhancer is dimethyl sulfoxide, the pH regulator is sodium hydroxide, and the excipient is polypropylene.

[0020] The dosage form of the above-mentioned Bupleurum volatile oil external preparation is an ointment.

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Abstract

The invention provides an external preparation of bupleurum volatile oil, which is characterized in that the preparation consists of bupleurum volatile oil, peppermint extract, solvent, surfactant, skin penetration enhancer, pH-value regulator and excipient, wherein, of the total weight, the preparation contains 0.1-10 percent of bupleurum volatile oil, 0.1-20 percent of auxiliary components of peppermint extract; 5-50 percent of solvent, 0.1-30 percent of surfactant or cosolvent, 0.1-20 percent of skin penetration enhancer, 0.1-10 percent of pH-value regulator and 20-95 percent of excipient. The invention has the advantages that: (1) after being produced into the external preparation, the effect thereof can be better; (2) the external preparation has convenient clinical use, the effect is obviously superior to the similar products; (3) the bupleurum volatile oil belongs to natural products, has fast effect with small side-effect.

Description

(1) Technical field: [0001] The invention relates to an external preparation, in particular to an external preparation of bupleurum volatile oil. (two) background technology: [0002] The traditional Chinese medicine Bupleurum bupleurum is a pungent and good-relieving superficial medicine, bitter in nature, slightly cold, and returns to the liver and gallbladder meridians, and has the effects of dispersing and reducing fever, soothing the liver, and promoting yang. The volatile oil extracted from Bupleurum bupleuri not only has the advantages of low toxicity, but also has a very significant antipyretic effect. Generally, Bupleurum volatile oil is prepared into injections clinically. Although the curative effect is good like this, the way of administration is very inconvenient, and the existing dosage forms are less and are single preparations. It is very necessary to obtain the Bupleurum volatile oil topical preparation with the best effect. (3) Contents of the invention:...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/00A61K9/06A61K9/107A61K9/70A61K47/10A61K47/12A61K47/20A61K47/32A61K47/34A61K47/38A61P11/00A61P29/00A61P31/12A61K125/00
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV
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