Panax japonicus total saponins preparation and its applications in medicament for curing myocardial ischemia

Abstract

The invention relates to a preparation method of total rhizoma panacis japonica saponins and the application thereof in the medicine for treating myocardial ischemia. Coarse powder of panax japonicus medicinal material is obtained, and coarse sizing ethanol solution is added in to dip in; the solution is extracted after being heated and refluxed, and the extracting solution is merged; the solution is decompressed to recover solvent until no odor of ethanol exists; the solvent is dilluted with water and is let stand, and the solution is centrifugated to obtain supernatant fluid; the supernatant fluid is extracted by using normal butanol containing water in an equivalent way, and the extract liquid is merged; the merged extract liquid is decompressed to recover the solvent until no normal butanol is distilled; thick extract is fully dissolved by using the ethanol solution of 85 percent, and acetone is added in slowly and the stirring is performed at the same time; then the solution is let stand under a normal temperature to lead the precipitate to be fully separated and is centrifugated, the precipitate is collected and is washed by the acetone, and the total rhizoma panacis japonica saponins is obtained after being dried. The invention can simply and effectively extract the total rhizoma panacis japonica saponins from the panax japonicus, the maximum metastasis rate of the total rhizoma panacis japonica saponins can reach 97.81 percent to show that the extraction technology is more stable and reliable, and the extraction rate is higher; the medicine which is obtained by utilizing the total rhizoma panacis japonica saponins as a main constituent has better curative effect for treating the myocardial ischemia.

Description

technical field [0001] The invention relates to a preparation method of total bamboo ginseng saponins, and also relates to the application of total bamboo ginseng saponins in medicine for treating myocardial ischemia. Background technique [0002] Bamboo ginseng, also known as bamboo ginseng, bamboo ginseng, white notoginseng, etc., is the dried root of Panaxjaponicus C.A.Mey., a plant of the genus Araliaceae, which is in the shape of a bamboo whip. expectorant effect. The main active ingredients of bamboo ginseng are saponins, and more than 20 kinds of saponins have been isolated and identified. The chemical structure is mainly oleanane-type saponins, which can generate oleanolic acid after hydrolysis. Modern pharmacological studies have shown that the total saponins and water extracts of bamboo ginseng have obvious anti-inflammatory, anti-oxidation, and hypoglycemic effects. At present, there are not many research reports on the extraction and purification of total sapon...

AI Technical Summary

Problems solved by technology

At present, there are not many research reports on the extraction and purification of total saponins in Panax ginseng, and there are no reports on pharmaceutical preparations with total saponins in Panax ginseng as the basic active ingredient.

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