Disinfection sterilizing type medical supersonic couplant and method of preparing the same

An ultrasonic couplant, disinfection and sterilization technology, applied in pharmaceutical formulations, preparations for in vivo experiments, etc., can solve the problems of sound wave conduction and image clarity, cumbersome operation, and lack of sterility, and achieve fast and long-term effects. The effect of bactericidal function

Active Publication Date: 2008-08-27
广州市一杰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to avoid cross-infection during ultrasonic detection of the mucous membrane of the cavity, the probe is often coated with an ultrasonic coupling agent and then covered with a condom for detection. In order to facilitate the insertion of the probe into the cavity, an ultrasonic coupling agent is often applied outside the condom Lubrication method is used for detection, which is extremely cumbersome to operate
The general ultrasonic coupling agent not only fails to meet the requirements of sterility, but

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prepare according to the following components and weight percentages

[0015] 0.05-0.15% of polyhexamethylene biguanide, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance is deionized water.

[0016] Preparation method: disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80 ° C, keep the temperature for 30 minutes, when the liquid is transparent, cool to 45 ° C, add polyhexamethylene biguanide, stir and cool , and finally canned.

[0017] Take the preparation of 1000kg of this medical ultrasonic couplant as an example, and weigh it according to the following weight

[0018] The concentration is 5kg of 20% polyhexamethylene biguanide, 20kg of hydroxyethyl cellulose, 100kg of propylene glycol, and 875kg of deionized water.

[0019] Preparation method: Disperse 20kg of hydroxyethyl cellulose in 100kg of propylene glycol, add 875kg of deionized water, heat to 80°C for dissolving for ...

Embodiment 2

[0021] Prepare according to the following components and weight percentages

[0022] 0.01-0.1% of polyhexamethylene biguanide, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance being deionized water.

[0023] Preparation method: under the requirement that polyhexamethylene biguanide + chlorhexidine acetate is 0.05 to 0.15%, respectively weigh polyhexamethylene biguanide and chlorhexidine acetate within the above ranges of polyhexamethylene biguanide and chlorhexidine acetate. Chlorhexidine acetate, then disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75-80 ℃, keep the temperature for 30 minutes, when the liquid is transparent, cool to 45 ℃, add polyhexamethylene The base biguanide and chlorhexidine acetate are stirred and cooled, and finally canned.

Embodiment 3

[0025] Prepare according to the following components and weight percentages

[0026] 0.01-0.1% of benzalkonium chloride, 0.01-0.1% of chlorhexidine acetate, 0.1-0.2% of hydroxyethyl cellulose, 1-10% of propylene glycol, and the balance being deionized water.

[0027] Preparation method: disperse hydroxyethyl cellulose in propylene glycol, add enough deionized water to stir and disperse, heat to 75~80℃, keep warm for 30min, when the liquid is transparent, cool to 45℃, add benzalkonium chloride and acetic acid chloride It has to be stirred and cooled, and finally canned.

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Abstract

The invention discloses a disinfection sterilization medical ultrasonic coupling medium with the bactericidal function and used in the ultrasonic detection and treatment of skin and cavitary mucosa and a preparation method of the coupling medium, wherein, the ultrasonic coupling medium comprises propylene glycol, de-ionized water and one viscosity modifier of the hydroxy ethyl cellulose, carbomer and hydroxy propyl cellulose. The coupling medium further comprises a fungicide of 0.05 to 0.15 percent and the constituents of the fungicide are any one of polyhexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, trichlorobenzene phenoxy diphenyl ether and nanometer silver or any combination of the olyhexamethylene biguanide, the benzalkonium chloride, the benzalkonium bromide, the chlorhexidine acetate, the trichlorobenzene phenoxy diphenyl etherand, and the nanometer silver; the preparation method used for preparing the ultrasonic coupling medium is as follows: dispersing the hydroxy ethyl cellulose in the propylene glycol, stirring and dispersing the hydroxy ethyl cellulose by adding enough water, heating to 75 to 80 DEG C, preserving the heat for 30 minutes to cool the hydroxy ethyl cellulose and the propylene glycol to 45 DEG C, adding the fungicide to stir and cool the fungicide, the hydroxy ethyl cellulose and the propylene glycol to obtain the filled coupling medium. Tests show that the products of the coupling medium have fast and long sterilization effect and meet the requirements of various related standards.

Description

technical field [0001] The invention relates to a medical ultrasonic coupling agent, in particular to a sterilizing and sterilizing medical ultrasonic coupling agent with sterilization function used for ultrasonic detection and treatment of skin and cavity mucosa and a preparation method thereof. Background technique [0002] In the prior art, the medical ultrasonic coupling agent is mainly prepared from one of the viscosity modifiers such as hydroxyethyl cellulose, carbomer, hydroxypropyl cellulose, propylene glycol solvent and deionized water. The ultrasonic couplant is often used in clinical ultrasonic diagnosis and treatment, and acts as a coupling between the sound head (ultrasonic probe or treatment head) and the object to be measured, so that the sound waves can smoothly enter the body to obtain reliable images or reach the treated tissue. The basic requirement is that it can transmit sound waves effectively, and the acoustic impedance rate is between the acoustic imp...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 伍于添
Owner 广州市一杰医药科技有限公司
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